European Journal of Nuclear Medicine

, Volume 28, Issue 2, pp 209–213

99mTc-MIBI scintigraphy of parathyroid adenomas and its relation to tumour size and oxyphil cell abundance

  • Moshe Melloul
  • Adrian Paz
  • Rumelia Koren
  • Shmuel Cytron
  • Rafael Feinmesser
  • Rivka Gal
Original Article

DOI: 10.1007/s002590000406

Cite this article as:
Melloul, M., Paz, A., Koren, R. et al. Eur J Nucl Med (2001) 28: 209. doi:10.1007/s002590000406

Abstract

The aim of this study was to assess the correlation between technetium-99m methoxyisobutylisonitrile (MIBI) uptake by parathyroid adenomas, oxyphil cell content and volume of the lesions. Thirty-one patients with parathyroid adenomas were evaluated prospectively. Preoperative double-phase 99mTc-MIBI scintigraphy was performed in all patients and tracer uptake by parathyroid lesions was assessed semi-quantitatively employing region of interest ratios to normal adjacent neck areas. Surgical specimens underwent histological evaluation and oxyphil cell content was determined. The intensity of tracer uptake was compared with oxyphil cell content, volume of the lesions and serum levels of calcium and parathormone. 99mTc-MIBI tracer uptake was correlated with oxyphil cell content, volume of parathyroid lesions and the functional status of the parathyroid adenomas. Tracer accumulation in oxyphil cells might partially explain the preferential 99mTc-MIBI retention in parathyroid lesions.

99mTc-MIBI Parathyroid adenoma Parathyroid volume Oxyphil cell content 

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Moshe Melloul
    • 1
  • Adrian Paz
    • 1
  • Rumelia Koren
    • 2
  • Shmuel Cytron
    • 1
  • Rafael Feinmesser
    • 3
  • Rivka Gal
    • 2
  1. 1.Department of Nuclear Medicine, Hasharon Hospital, Campus Golda, Rabin Medical Center, 7, Keren-Kayemet Street, Petah Tikva, 49372 IsraelIsrael
  2. 2.Department of Pathology, Hasharon Hospital, Campus Golda, Rabin Medical Center, Petah Tikva, IsraelIsrael
  3. 3.Department of Oto-Rhino-Laryngology, Hasharon Hospital, Campus Golda, Rabin Medical Center, Petah Tikva, IsraelIsrael

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