European Journal of Nuclear Medicine and Molecular Imaging

, Volume 41, Issue 8, pp 1497–1500

Thyroid nodules with indeterminate cytology: molecular imaging with 99mTc-methoxyisobutylisonitrile (MIBI) is more cost-effective than the Afirma® gene expression classifier

  • Alexander Heinzel
  • Dirk Müller
  • Florian F. Behrendt
  • Luca Giovanella
  • Felix M. Mottaghy
  • Frederik A. Verburg
Short Communication

DOI: 10.1007/s00259-014-2760-4

Cite this article as:
Heinzel, A., Müller, D., Behrendt, F.F. et al. Eur J Nucl Med Mol Imaging (2014) 41: 1497. doi:10.1007/s00259-014-2760-4

Abstract

Purpose

To compare the cost-effectiveness of 99mTc-methoxyisobutylisonitrile (MIBI) thyroid scintigraphy and the Afirma® gene expression classifier for the assessment of cytologically indeterminate thyroid nodules.

Methods

A decision tree model was used. Costs were calculated from the perspective of the German health insurance system. The robustness of the results was assessed with probabilistic sensitivity analyses using a Monte Carlo simulation.

Results

Life expectancy was 34.3 years (estimated costs per patient €1,459 – €2,224) for the MIBI scan and 34.1 years (estimated costs €3,560 – €4,071) for the molecular test. These results were confirmed by the Monte Carlo simulation.

Conclusion

MIBI thyroid scintigraphy is more cost-effective than the gene expression classifier.

Keywords

99mTc-Methoxyisobutylisonitrile (MIBI)Thyroid noduleAfirma® gene expression classifierCost-effectiveness

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Alexander Heinzel
    • 1
    • 2
  • Dirk Müller
    • 3
  • Florian F. Behrendt
    • 1
  • Luca Giovanella
    • 4
  • Felix M. Mottaghy
    • 1
    • 5
  • Frederik A. Verburg
    • 1
    • 5
  1. 1.Department of Nuclear MedicineRWTH Aachen University HospitalAachenGermany
  2. 2.Institute for Neuroscience and Medicine (INM-4), Research CentreJülichGermany
  3. 3.Institute for Health Economics and Clinical EpidemiologyUniversity of CologneCologneGermany
  4. 4.Department of Nuclear Medicine OncologyInstitute of Southern SwitzerlandBelinzonaSwitzerland
  5. 5.Department of Nuclear MedicineMaastricht University Medical CenterMaastrichtThe Netherlands