European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
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Dopamine transporter (DAT) imaging with [123I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [123I]FP-CIT SPECT scans in healthy controls.
SPECT data from 139 healthy controls (74 men, 65 women; age range 20 – 83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectation-maximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR).
A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade.
This study provides a large database of [123I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference database for nuclear medicine centres and for clinical trials using [123I]FP-CIT SPECT as the imaging marker.
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- European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
European Journal of Nuclear Medicine and Molecular Imaging
Volume 40, Issue 2 , pp 213-227
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Dopamine transporter
- Gender difference
- Age effects
- Scatter correction
- Industry Sectors
- Andrea Varrone (1)
- John C. Dickson (2)
- Livia Tossici-Bolt (3)
- Terez Sera (4)
- Susanne Asenbaum (5)
- Jan Booij (6)
- Ozlem L. Kapucu (7)
- Andreas Kluge (8)
- Gitte M. Knudsen (9)
- Pierre Malick Koulibaly (10)
- Flavio Nobili (11)
- Marco Pagani (12) (13)
- Osama Sabri (14)
- Thierry Vander Borght (15)
- Koen Van Laere (16)
- Klaus Tatsch (17)
- Author Affiliations
- 1. Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, R5:02, 17176, Stockholm, Sweden
- 2. Institute of Nuclear Medicine, UCLH NHS Foundation Trust and University College, London, UK
- 3. Department of Medical Physics, University Hospitals Southampton NHS Trust, Southampton, UK
- 4. Department of Nuclear Medicine and Euromedic Szeged, University of Szeged, Szeged, Hungary
- 5. Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
- 6. Department of Nuclear Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
- 7. Department of Nuclear Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey
- 8. ABX-CRO, Dresden, Germany
- 9. Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
- 10. Nuclear Medicine Department, Centre Antoine Lacassagne, University of Nice-Sophia Antipolis, Nice, France
- 11. Clinical Neurophysiology Unit, Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
- 12. Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
- 13. Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
- 14. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
- 15. Nuclear Medicine Division, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium
- 16. Nuclear Medicine, University Hospital and K.U. Leuven, Leuven, Belgium
- 17. Department of Nuclear Medicine, Municipal Hospital of Karlsruhe Inc, Karlsruhe, Germany