European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
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Dopamine transporter (DAT) imaging with [123I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [123I]FP-CIT SPECT scans in healthy controls.
SPECT data from 139 healthy controls (74 men, 65 women; age range 20 – 83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectation-maximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR).
A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade.
This study provides a large database of [123I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference database for nuclear medicine centres and for clinical trials using [123I]FP-CIT SPECT as the imaging marker.
- Tatsch K. Can SPET imaging of dopamine uptake sites replace PET imaging in Parkinson’s disease? For. Eur J Nucl Med Mol Imaging. 2002;29:711–4. CrossRef
- Marshall V, Grosset DG. Role of dopamine transporter imaging in the diagnosis of atypical tremor disorders. Mov Disord. 2003;18 Suppl 7:S22–7. CrossRef
- Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E, et al. Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord. 2000;15:503–10. CrossRef
- Catafau AM, Tolosa E. Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes. Mov Disord. 2004;19:1175–82. CrossRef
- McKeith I, O’Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305–13. CrossRef
- Darcourt J, Booij J, Tatsch K, Varrone A, Vander Borght T, Kapucu OL, et al. EANM procedure guidelines for brain neurotransmission SPECT using (123)I-labelled dopamine transporter ligands, version 2. Eur J Nucl Med Mol Imaging. 2010;37:443–50. CrossRef
- Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C, et al. Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study. Ann Neurol. 2003;54:93–101. CrossRef
- Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson’s disease. N Engl J Med. 2004;351:2498–508. CrossRef
- van Dyck CH, Seibyl JP, Malison RT, Laruelle M, Wallace E, Zoghbi SS, et al. Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CITSPECT. J Nucl Med. 1995;36:1175–81.
- Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med. 2000;27:867–9. CrossRef
- de Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, et al. Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community concerted action on the epidemiology of Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1997;62:10–5. CrossRef
- de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, Baldereschi M, et al. Prevalence of Parkinson’s disease in Europe: a collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology. 2000;54:S21–3.
- Wooten GF, Currie LJ, Bovbjerg VE, Lee JK, Patrie J. Are men at greater risk for Parkinson’s disease than women? J Neurol Neurosurg Psychiatry. 2004;75:637–9. CrossRef
- Derogatis LR, Lipman RS, Covi L. SCL-90: an outpatient psychiatric rating scale – preliminary report. Psychopharmacol Bull. 1973;9:13–28.
- Beck AT, Steer RA. Beck depression inventory – manual. San Antonio: The Psychological Association; 1987.
- de Leeuw FE, de Groot JC, Achten E, Oudkerk M, Ramos LM, Heijboer R, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam scan study. J Neurol Neurosurg Psychiatry. 2001;70:9–14. CrossRef
- Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97–113. CrossRef
- Dickson JC, Tossici-Bolt L, Sera T, de Nijs R, Booij J, Bagnara MC, et al. Proposal for the standardisation of multi-centre trials in nuclear medicine imaging: prerequisites for a European 123I-FP-CIT SPECT database. Eur J Nucl Med Mol Imaging. 2012;39:188–97. CrossRef
- Tossici-Bolt L, Dickson JC, Sera T, de Nijs R, Bagnara MC, Jonsson C, et al. Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database. Eur J Nucl Med Mol Imaging. 2011;38:1529–40. CrossRef
- Ichihara T, Ogawa K, Motomura N, Kubo A, Hashimoto S. Compton scatter compensation using the triple-energy window method for single- and dual-isotope SPECT. J Nucl Med. 1993;34:2216–21.
- Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging. 1994;13:601–9. CrossRef
- Dickson JC, Tossici-Bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, et al. The impact of reconstruction method on the quantification of DaTSCAN images. Eur J Nucl Med Mol Imaging. 2010;37:23–35. CrossRef
- Ogawa K, Harata Y, Ichihara T, Kubo A, Hashimoto S. A practical method for position-dependent Compton-scatter correction in single photon emission CT. IEEE Trans Med Imaging. 1991;10:408–12. CrossRef
- Koch W, Suessmair C, Tatsch K, Popperl G. Iterative reconstruction or filtered backprojection for semi-quantitative assessment of dopamine D receptor SPECT studies? Eur J Nucl Med Mol Imaging. 2011;38:1095–103. CrossRef
- Tossici-Bolt L, Hoffmann SM, Kemp PM, Mehta RL, Fleming JS. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging. 2006;33:1491–9. CrossRef
- Gunning-Dixon FM, Head D, McQuain J, Acker JD, Raz N. Differential aging of the human striatum: a prospective MR imaging study. AJNR Am J Neuroradiol. 1998;19:1501–7.
- Cohen J, Cohen P, West SG, Aiken LS. Applied multiple regression/correlation analysis for the behavioral sciences. Mahwah: Erlbaum; 2003.
- Staley JK, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl JP, et al. Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse. 2001;41:275–84. CrossRef
- Mozley LH, Gur RC, Mozley PD, Gur RE. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry. 2001;158:1492–9. CrossRef
- Ryding E, Lindstrom M, Bradvik B, Grabowski M, Bosson P, Traskman-Bendz L, et al. A new model for separation between brain dopamine and serotonin transporters in 123I-beta-CIT SPECT measurements: normal values and sex and age dependence. Eur J Nucl Med Mol Imaging. 2004;31:1114–8. CrossRef
- van Dyck CH, Seibyl JP, Malison RT, Laruelle M, Zoghbi SS, Baldwin RM, et al. Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries. Am J Geriatr Psychiatry. 2002;10:36–43.
- Sanchez MG, Morissette M, Di Paolo T. Effect of a chronic treatment with 17beta-estradiol on striatal dopamine neurotransmission and the Akt/GSK3 signaling pathway in the brain of ovariectomized monkeys. Psychoneuroendocrinology. 2012;37:280–91. CrossRef
- Barnden LR, Dickson J, Hutton BF. Detection and validation of the body edge in low count emission tomography images. Comput Methods Programs Biomed. 2006;84:153–61. CrossRef
- European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
European Journal of Nuclear Medicine and Molecular Imaging
Volume 40, Issue 2 , pp 213-227
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Dopamine transporter
- Gender difference
- Age effects
- Scatter correction
- Industry Sectors
- Andrea Varrone (1)
- John C. Dickson (2)
- Livia Tossici-Bolt (3)
- Terez Sera (4)
- Susanne Asenbaum (5)
- Jan Booij (6)
- Ozlem L. Kapucu (7)
- Andreas Kluge (8)
- Gitte M. Knudsen (9)
- Pierre Malick Koulibaly (10)
- Flavio Nobili (11)
- Marco Pagani (12) (13)
- Osama Sabri (14)
- Thierry Vander Borght (15)
- Koen Van Laere (16)
- Klaus Tatsch (17)
- Author Affiliations
- 1. Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, R5:02, 17176, Stockholm, Sweden
- 2. Institute of Nuclear Medicine, UCLH NHS Foundation Trust and University College, London, UK
- 3. Department of Medical Physics, University Hospitals Southampton NHS Trust, Southampton, UK
- 4. Department of Nuclear Medicine and Euromedic Szeged, University of Szeged, Szeged, Hungary
- 5. Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
- 6. Department of Nuclear Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
- 7. Department of Nuclear Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey
- 8. ABX-CRO, Dresden, Germany
- 9. Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
- 10. Nuclear Medicine Department, Centre Antoine Lacassagne, University of Nice-Sophia Antipolis, Nice, France
- 11. Clinical Neurophysiology Unit, Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
- 12. Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
- 13. Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
- 14. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
- 15. Nuclear Medicine Division, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium
- 16. Nuclear Medicine, University Hospital and K.U. Leuven, Leuven, Belgium
- 17. Department of Nuclear Medicine, Municipal Hospital of Karlsruhe Inc, Karlsruhe, Germany