European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 5, pp 792–799

Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs

Authors

    • Department of Paediatric ResearchOslo University Hospital, Rikshospitalet
    • Department of Radiology and Nuclear MedicineOslo University Hospital, Rikshospitalet
  • Eirik Malinen
    • Department of Medical PhysicsOslo University Hospital
    • Department of PhysicsUniversity of Oslo
  • Hong Qu
    • Centre for Molecular Biology and Neuroscience, Department of Anatomy, Institute of Basic Medical SciencesUniversity of Oslo
  • Kjersti Johnsrud
    • Department of Radiology and Nuclear MedicineOslo University Hospital, Rikshospitalet
  • Arne Skretting
    • The Intervention CentreOslo University Hospital
  • Ola Didrik Saugstad
    • Department of Paediatric ResearchOslo University Hospital, Rikshospitalet
    • Department of MedicineUniversity of Oslo
  • Berit H. Munkeby
    • Department of Paediatric ResearchOslo University Hospital, Rikshospitalet
Original Article

DOI: 10.1007/s00259-011-2055-y

Cite this article as:
de Lange, C., Malinen, E., Qu, H. et al. Eur J Nucl Med Mol Imaging (2012) 39: 792. doi:10.1007/s00259-011-2055-y

Abstract

Purpose

Changes in cerebral glucose metabolism may be an early prognostic indicator of perinatal hypoxic–ischaemic injury. In this study dynamic 18F-FDG PET was used to evaluate cerebral glucose metabolism in piglets after global perinatal hypoxia and the impact of the resuscitation strategy using room air or hyperoxia.

Methods

New-born piglets (n = 16) underwent 60 min of global hypoxia followed by 30 min of resuscitation with a fraction of inspired oxygen (FiO2) of 0.21 or 1.0. Dynamic FDG PET, using a microPET system, was performed at baseline and repeated at the end of resuscitation under stabilized haemodynamic conditions. MRI at 3 T was performed for anatomic correlation. Global and regional cerebral metabolic rates of glucose (CMRgl) were assessed by Patlak analysis for the two time-points and resuscitation groups.

Results

Global hypoxia was found to cause an immediate decrease in cerebral glucose metabolism from a baseline level (mean ± SD) of 21.2 ± 7.9 to 12.6 ± 4.7 μmol/min/100 g (p <0.01). The basal ganglia, cerebellum and cortex showed the greatest decrease in CMRgl but no significant differences in global or regional CMRgl between the resuscitation groups were found.

Conclusion

Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMRgl may indicate early changes of mild cerebral hypoxia–ischaemia. No significant effect of hyperoxic resuscitation on the degree of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of perinatal hypoxic–ischaemic injury where early detection plays an important role in instituting therapy.

Keywords

Glucose metabolismFDG PETPerinatal hypoxia–ischaemiaPiglet

Copyright information

© Springer-Verlag 2012