Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs
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Changes in cerebral glucose metabolism may be an early prognostic indicator of perinatal hypoxic–ischaemic injury. In this study dynamic 18F-FDG PET was used to evaluate cerebral glucose metabolism in piglets after global perinatal hypoxia and the impact of the resuscitation strategy using room air or hyperoxia.
New-born piglets (n = 16) underwent 60 min of global hypoxia followed by 30 min of resuscitation with a fraction of inspired oxygen (FiO2) of 0.21 or 1.0. Dynamic FDG PET, using a microPET system, was performed at baseline and repeated at the end of resuscitation under stabilized haemodynamic conditions. MRI at 3 T was performed for anatomic correlation. Global and regional cerebral metabolic rates of glucose (CMRgl) were assessed by Patlak analysis for the two time-points and resuscitation groups.
Global hypoxia was found to cause an immediate decrease in cerebral glucose metabolism from a baseline level (mean ± SD) of 21.2 ± 7.9 to 12.6 ± 4.7 μmol/min/100 g (p <0.01). The basal ganglia, cerebellum and cortex showed the greatest decrease in CMRgl but no significant differences in global or regional CMRgl between the resuscitation groups were found.
Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMRgl may indicate early changes of mild cerebral hypoxia–ischaemia. No significant effect of hyperoxic resuscitation on the degree of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of perinatal hypoxic–ischaemic injury where early detection plays an important role in instituting therapy.
- Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs
European Journal of Nuclear Medicine and Molecular Imaging
Volume 39, Issue 5 , pp 792-799
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- Glucose metabolism
- FDG PET
- Perinatal hypoxia–ischaemia
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- Author Affiliations
- 1. Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, P.O. Box 4950, Nydalen, 0424, Oslo, Norway
- 3. Department of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, P.O. Box 4950, Nydalen, 0424, Oslo, Norway
- 2. Department of Medical Physics, Oslo University Hospital, P.O. Box 4953, Nydalen, 0424, Oslo, Norway
- 6. Department of Physics, University of Oslo, P.O. Box 1048, Blindern, 0316, Oslo, Norway
- 5. Centre for Molecular Biology and Neuroscience, Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1105, Blindern, 0317, Oslo, Norway
- 4. The Intervention Centre, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway
- 7. Department of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316, Oslo, Norway