Review Article

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 3, pp 533-542

First online:

Imaging the islet graft by positron emission tomography

  • Olof ErikssonAffiliated withPreclinical PET Platform, Department of Medicinal Chemistry, Uppsala University Email author 
  • , Abass AlaviAffiliated withDepartment of Radiology, Hospital of the University of Pennsylvania

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Clinical islet transplantation is being investigated as a permanent cure for type 1 diabetes mellitus (T1DM). Currently, intraportal infusion of islets is the favoured procedure, but several novel implantation sites have been suggested. Noninvasive longitudinal methodologies are an increasingly important tool for assessing the fate of transplanted islets, their mass, function and early signs of rejection. This article reviews the approaches available for islet graft imaging by positron emission tomography and progress in the field, as well as future challenges and opportunities.


Islet transplantation Islet imaging Rejection Beta cell mass Positron emission tomography