European Journal of Nuclear Medicine and Molecular Imaging

, Volume 38, Issue 12, pp 2202–2208

In vivo imaging of astrocytosis in Alzheimer’s disease: an 11C-L-deuteriodeprenyl and PIB PET study

Authors

    • Geriatric Psychiatry, Department of Clinical MedicineLund University
    • Department of Public Health and Caring Sciences/GeriatricsUppsala University
  • Juan Pablo Gambini
    • Faculty of Medicine and Faculty of ScienceUniversity of the Republic
    • Uruguayan Centre of Molecular Imaging (CUDIM)
  • Lars Lannfelt
    • Department of Public Health and Caring Sciences/GeriatricsUppsala University
  • Bengt Långström
    • Departments of Biochemistry and Organic ChemistryUppsala University
  • Luohija Ulla-Marja
    • Helsinki University Hospital
    • Department of Medical Sciences, Clinical PhysiologyUppsala University
  • Lena Kilander
    • Department of Public Health and Caring Sciences/GeriatricsUppsala University
  • Henry Engler
    • Faculty of Medicine and Faculty of ScienceUniversity of the Republic
    • Uruguayan Centre of Molecular Imaging (CUDIM)
Original Article

DOI: 10.1007/s00259-011-1895-9

Cite this article as:
Santillo, A.F., Gambini, J.P., Lannfelt, L. et al. Eur J Nucl Med Mol Imaging (2011) 38: 2202. doi:10.1007/s00259-011-1895-9

Abstract

Purpose

Astrocytosis is an important feature of the neuropathology of Alzheimer’s disease (AD), yet there is currently no way of detecting this phenomenon in vivo.

Methods

In this study we examine the retention of the positron emission tomography (PET) tracer 11C-L-deuteriodeprenyl (DED), thought to bind activated astrocytes, in 9 patients with moderate to severe AD compared with 11 healthy controls. As a measure of amyloid load, 11C-labelled Pittsburgh Compound B (PIB) retention was determined.

Results

Results show a significantly higher 11C-L-DED retention in the frontal (35.1% increase, p = 0.001), parietal (35.2%, p = 0.001), temporal (30.9%, p = 0.0001) and medial temporal lobes (22.3%, p = 0.001) in AD compared to healthy controls after blood flow correction. DED retention in the sensorimotor and occipital cortices, and in white matter and subcortical structures, did not differ between groups. There was a moderate but statistically significant (r = 0.492, p = 0.01) correlation between DED and PIB retention values.

Conclusion

Our conclusion is that DED may serve as an in vivo marker for astrocytosis in AD, providing a window into intermediate processes between amyloidosis and neuronal loss and a means of monitoring immunotherapy.

Keywords

11C-L-deuteriodeprenylPittsburgh Compound BAstrocytosisAlzheimer’s diseasePositron emission tomography

Copyright information

© Springer-Verlag 2011