Review Article

European Journal of Nuclear Medicine and Molecular Imaging

, 38:1939

First online:

Evolving role of FDG PET imaging in assessing joint disorders: a systematic review

  • Kathleen CareyAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Babak SabouryAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Sandip BasuAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Alex BrothersAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Alexis OgdieAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Tom WernerAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Drew A. TorigianAffiliated withDepartment of Radiology, School of Medicine, University of Pennsylvania
  • , Abass AlaviAffiliated withDepartment of Radiology, School of Medicine, University of PennsylvaniaDepartment of Radiology, Hospital of the University of Pennsylvania Email author 

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Abstract

Assessing joint disorders has been a relatively recent and evolving application of 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) imaging. FDG is taken up by inflammatory cells, particularly when they are active as part of an ongoing inflammatory process. Hence FDG PET has been employed to assess a wide array of arthritic disorders. FDG PET imaging has been investigated in various joint diseases for diagnostic purposes, treatment monitoring, and as a prognostic indicator as in other disorders. In some of the diseases the ancillary findings in FDG PET have provided important clues about the underlying pathophysiology and pathogenesis processes. While substantial promise has been demonstrated in a number of studies, it is clear that the potential utility of PET in this clinical realm far outweighs that which has been established to date.

Keywords

18F-Fluorodeoxyglucose Positron emission tomography Arthritis Osteoarthritis Inflammation