Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer
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The Response Evaluation Criteria in Solid Tumors (RECIST) are widely used but have recognized limitations. Molecular imaging assessments, including changes in 18F-deoxyglucose (FDG) or 18F-deoxythymidine (FLT) uptake by positron emission tomography (PET), may provide earlier, more robust evaluation of treatment efficacy.
A prospective trial evaluated on-treatment changes in FDG and FLT PET imaging among patients with relapsed or recurrent non-small cell lung cancer treated with erlotinib to assess the relationship between PET-evaluated response and clinical outcomes. We describe an audit of compliance with the study imaging charter, to establish the feasibility of achieving methodological consistency in a multicentre setting.
Patients underwent PET scans at baseline and approximately day 14 and day 56 of treatment (n = 73, 66 and 51 studies, and n = 73, 63 and 50 studies for FDG PET and FLT PET, respectively). Blood glucose levels were within the target range for all FDG PET scans. Charter-specified uptake times were achieved in 86% (63/73) and 89% (65/73) of baseline FDG and FLT scans, respectively. On-treatment scans were less consistent: 72% (84/117) and 68% (77/113), respectively, achieved the target of ±5 min of baseline uptake time. However, 96% (112/117) and 94% (106/113) of FDG and FLT PET studies, respectively, were within ±15 min. Bland-Altman analysis of intra-individual hepatic average standardized uptake value (SUVave), to assess reproducibility, showed only a small difference in physiological uptake (−0.006 ± 0.224 in 118 follow-up FDG scans and 0.09 ± 0.81 in 111 follow-up FLT scans).
It is possible to achieve high reproducibility of scan acquisition methodology, provided that strict imaging compliance guidelines are mandated in the study protocol.
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- Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer
European Journal of Nuclear Medicine and Molecular Imaging
Volume 38, Issue 4 , pp 642-650
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- PET acquisition protocols
- Erlotinib therapy
- Non-small cell lung cancer
- Industry Sectors
- Author Affiliations
- 1. The Peter MacCallum Cancer Centre, Melbourne, Australia
- 2. Genentech, Inc., South San Francisco, CA, USA
- 3. University of Southern California Kenneth Norris Medical Center, Los Angeles, CA, USA
- 4. Centre for PET, and Ludwig Institute for Cancer Research, The University of Melbourne and The Austin Hospital, Victoria, Australia
- 5. Queensland PET Service, Royal Brisbane and Women’s Hospital, Brisbane, Australia
- 6. Departments of Medicine and Radiology, The University of Melbourne and The Peter MacCallum Cancer Centre, 12 St Andrew’s Place, East Melbourne, VIC, 3002, Australia