FDG positron emission tomography/computed tomography studies of Wilms’ tumor

  • A. K. M. Moinul Hossain
  • Barry L. Shulkin
  • Michael J. Gelfand
  • Humayun Bashir
  • Najat C. Daw
  • Susan E. Sharp
  • Helen R. Nadel
  • Jeffrey S. Dome
Original Article

DOI: 10.1007/s00259-010-1396-2

Cite this article as:
Moinul Hossain, A.K.M., Shulkin, B.L., Gelfand, M.J. et al. Eur J Nucl Med Mol Imaging (2010) 37: 1300. doi:10.1007/s00259-010-1396-2

Abstract

Purpose

The purpose of this analysis was to evaluate the utility of FDG PET/CT scanning in patients with Wilms’ tumors.

Methods

A total of 58 scans were performed in 27 patients (14 male, 13 female; ages: 1.9–23 years, median: 7 years) with proven Wilms’ tumor. Twenty-six patients (56 scans) were studied at the time of suspected relapse, progressive disease, persistent disease, or for monitoring of therapy.

Results

In the 27 patients with Wilms’ tumor, 34 scans showed areas of abnormal uptake consistent with metabolically active tumors. Of the patients, 8 (24 scans) had pulmonary metastases larger than 10 mm in diameter, 10 (12 scans) had hepatic metastases, 11 (11 scans) had regional nodal involvement, 3 (3 scans) had bone metastases, 1 (1 scan) had chest wall involvement, 2 (2 scans) had pancreatic metastasis, and 5 (5 scans) had abdominal and pelvic soft tissue involvement. Two of eight patients with lung metastases had variable uptakes. Lung lesions 10 mm or smaller were not consistently visualized on PET scans. One patient with a liver metastasis showed no uptake on PET scan after treatment (size decreased from 45 to 15 mm).

Conclusion

Most Wilms’ tumors concentrate FDG. However, small pulmonary metastases may be better visualized with CT. FDG PET/CT appears useful for defining the extent of involvement and assessing the response to treatment.

Keywords

FDG PET/CT Wilms’ tumor Metabolism FDG Pediatrics 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • A. K. M. Moinul Hossain
    • 1
  • Barry L. Shulkin
    • 1
  • Michael J. Gelfand
    • 2
  • Humayun Bashir
    • 3
  • Najat C. Daw
    • 4
  • Susan E. Sharp
    • 2
  • Helen R. Nadel
    • 5
  • Jeffrey S. Dome
    • 6
  1. 1.Nuclear Imaging Division, Department of Radiological Sciences, MS #220St. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of RadiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  3. 3.Medical ImagingKing Abdul Aziz Medical CityRiyadhSaudi Arabia
  4. 4.Department of OncologySt. Jude Children’s Research HospitalMemphisUSA
  5. 5.Division of Nuclear Medicine, Department of RadiologyBritish Columbia Children’s HospitalVancouverCanada
  6. 6.Division of OncologyChildren’s National Medical CenterWashingtonUSA