, Volume 37, Issue 5, p 1047,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 30 Jan 2010

High-resolution 18F-FDG PET with MRI for monitoring response to treatment in rheumatoid arthritis

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Molecular imaging can potentially provide means for monitoring response to therapy in rheumatoid arthritis (RA) early in the course of disease [1].Quantitative measurements of RA disease activity made in the wrist by whole-body PET scanners, however, have inadequate accuracy because of limited spatial resolution [2]. A high-resolution PET/CT scanner for imaging extremities has been built at our institution [3]. In conjunction with a clinical MRI scanner, high-resolution PET/MR images can be obtained for the wrist. The CT image is used for PET/MR image coregistration.

A 57-year-old female with established RA was stable until a recent clinical flare-up in the right wrist. Clinical examination revealed synovitis, swelling, and diminished range of motion. The patient also had a history of osteoarthritis (OA). An extremity 18F-FDG PET/CT scan immediately following MRI at baseline was performed on this patient. Tumor necrosis factor alpha (TNF-α) inhibitor (etanercept) therapy was then initia

This work was funded by the NIH grants UL1-RR024146, R01CA129561, R01EB002138 and the UC Davis Imaging Research Center.