European Journal of Nuclear Medicine and Molecular Imaging

, Volume 37, Issue 3, pp 589–593

Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer’s disease

Authors

    • Université Pierre et Marie Curie-Paris 6, INSERMUMR-S 678
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière, AP-HP
    • Department of Nuclear MedicineHôpital Pitié-Salpêtrière
  • Leonardo Cruz de Souza
    • Research and Resource Memory Centre and INSERM U610CHU Pitié-Salpêtrière, AP-HP
  • Foudil Lamari
    • Department of Metabolic BiochemistryCHU Pitié-Salpêtrière, AP-HP
  • Nelle Daragon
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière, AP-HP
  • Serge Desarnaud
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière, AP-HP
  • Claude Jardel
    • Department of Metabolic BiochemistryCHU Pitié-Salpêtrière, AP-HP
  • Bruno Dubois
    • Research and Resource Memory Centre and INSERM U610CHU Pitié-Salpêtrière, AP-HP
  • Marie Sarazin
    • Research and Resource Memory Centre and INSERM U610CHU Pitié-Salpêtrière, AP-HP
Short Communication

DOI: 10.1007/s00259-009-1285-8

Cite this article as:
Habert, M., de Souza, L.C., Lamari, F. et al. Eur J Nucl Med Mol Imaging (2010) 37: 589. doi:10.1007/s00259-009-1285-8

Abstract

Purpose

Our aim was to study the correlations between cerebrospinal fluid (CSF) biomarker levels such as β-amyloid 42 (Aβ42), total and phosphorylated tau protein (T-tau and P-tau) and brain perfusion SPECT in Alzheimer’s disease (AD) using a voxel-based methodology.

Methods

Patients (n = 31) with clinical features of AD (n = 25) or amnestic mild cognitive impairment (aMCI) (n = 6) were retrospectively included. All subjects underwent the same clinical, neuropsychological and neuroimaging tests. They had a lumbar puncture and a brain perfusion (99mTc-ECD) SPECT within a time interval of 10 (±26) days. Correlations between CSF biomarker concentrations and perfusion were studied using SPM2 software. Individual normalised regional activity values were extracted from the eligible clusters for calculation of correlation coefficients.

Results

No significant correlation was found between Aβ42 concentrations and brain perfusion. A significant correlation (p < 0.01, corrected) was found between T-tau or P-tau concentrations and perfusion in the left parietal cortex.

Conclusion

Our results suggest a strong correlation between T-tau and P-tau levels and decreased brain perfusion in regions typically affected by neuropathological changes in AD.

Keywords

SPECTrCBFAlzheimer’s diseaseMild cognitive impairmentCSF biomarkers

Supplementary material

259_2009_1285_Fig3_ESM.tif (879 kb)
High resolution image file (TIFF 879 kb).

Copyright information

© Springer-Verlag 2009