Sentinel lymph node biopsy in pregnant patients with breast cancer
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Sentinel lymph node biopsy (SLNB) is currently not recommended in pregnant patients with breast cancer due to radiation concerns.
Twelve pregnant patients with breast cancer received low-dose (10 MBq on average) lymphoscintigraphy using 99mTc human serum albumin nanocolloids.
The sentinel lymph node (SLN) was identified in all patients. Of the 12 patients, 10 had pathologically negative SLN. One patient had micrometastasis in one of four SLN. One patient had metastasis in the SLN and underwent axillary clearance. From the 12 pregnancies, 11 healthy babies were born with no malformations and normal weight. One baby, whose mother underwent lymphatic mapping during the 26th week of gestation, was operated on at the age of 3 months for a ventricular septal defect and at 43 months was in good health. This malformation was suspected at the morphological US examination during week 21, well before lymphoscintigraphy, and was confirmed a posteriori by a different observer based on videotaped material. No overt axillary recurrence appeared in the patients with negative SLNs after a median follow-up of 32 months.
Our experience supports the safety of SLNB in pregnant patients with breast cancer, when performed with a low-dose lymphoscintigraphic technique.
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- Sentinel lymph node biopsy in pregnant patients with breast cancer
European Journal of Nuclear Medicine and Molecular Imaging
Volume 37, Issue 1 , pp 78-83
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Sentinel node
- Breast cancer
- Industry Sectors
- Oreste Gentilini (1)
- Marta Cremonesi (2)
- Antonio Toesca (1)
- Nicola Colombo (3)
- Fedro Peccatori (4)
- Roberto Sironi (5)
- Claudia Sangalli (1)
- Nicole Rotmensz (6)
- Guido Pedroli (2)
- Giuseppe Viale (7) (8)
- Paolo Veronesi (1)
- Viviana Galimberti (1)
- Aron Goldhirsch (9)
- Umberto Veronesi (1) (10)
- Giovanni Paganelli (11)
- Author Affiliations
- 1. Division of Senology, European Institute of Oncology, Milan, Italy
- 2. Unit of Medical Physics, European Institute of Oncology, Milan, Italy
- 3. Unit of Cardiology, European Institute of Oncology, Milan, Italy
- 4. Division of Haematology-Oncology, European Institute of Oncology, Milan, Italy
- 5. Unit of Obstetrics and Gynecology, S. Pio X Hospital, Milan, Italy
- 6. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
- 7. Division of Pathology, European Institute of Oncology, Milan, Italy
- 8. University of Milan School of Medicine, Milan, Italy
- 9. Department of Medicine, European Institute of Oncology, Milan, Italy
- 10. European Institute of Oncology, Milan, Italy
- 11. Division of Nuclear Medicine, European Institute of Oncology, Via Ripamonti 435, 20141, Milano, Italy