Original Article

European Journal of Nuclear Medicine and Molecular Imaging

, 36:1574

First online:

18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma

  • Jeong Won LeeAffiliated withDepartment of Nuclear Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University
  • , Keon Wook KangAffiliated withDepartment of Nuclear Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National UniversityInstitute of Radiation Medicine, Seoul National University College of Medicine Email author 
  • , Sung-Hye ParkAffiliated withDepartment of Pathology, Seoul National University College of Medicine
  • , Sang Mi LeeAffiliated withDepartment of Nuclear Medicine, Seoul National University College of Medicine
  • , Jin Chul PaengAffiliated withDepartment of Nuclear Medicine, Seoul National University College of Medicine
  • , June-Key ChungAffiliated withDepartment of Nuclear Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National UniversityInstitute of Radiation Medicine, Seoul National University College of Medicine
  • , Myung Chul LeeAffiliated withDepartment of Nuclear Medicine, Seoul National University College of MedicineInstitute of Radiation Medicine, Seoul National University College of Medicine
  • , Dong Soo LeeAffiliated withDepartment of Nuclear Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National UniversityInstitute of Radiation Medicine, Seoul National University College of Medicine

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Abstract

Purpose

The purpose of this study was to investigate the role of 18F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection.

Methods

Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled. All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34±20 months. The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma. Further, univariate analysis with the log-rank test was performed to assess the predictive factors of meningioma recurrence.

Results

The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p=0.002) and significantly correlated with the MIB-1 labeling index (r=0.338, p=0.009) and mitotic count of the tumor (r=0.284, p=0.03). The ROC analysis revealed that the TGR of 1.0 was the best cutoff value for detecting high-grade meningioma with a sensitivity of 43%, specificity of 95%, and accuracy of 81%. Of 59 patients, 5 (9%) had a recurrent event. In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence. The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p=0.0003)

Conclusion

FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.

Keywords

Meningioma Positron emission tomography (PET) 18F-fluorodeoxyglucose (FDG) Recurrence Prognosis