European Journal of Nuclear Medicine and Molecular Imaging

, Volume 36, Issue 7, pp 1131–1137

18F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis

Authors

    • Department of Nuclear MedicineSt. Antonius Hospital Nieuwegein
  • Fred J. Verzijlbergen
    • Department of Nuclear MedicineSt. Antonius Hospital Nieuwegein
  • Wim J. Oyen
    • Department of Nuclear MedicineRadboud University Nijmegen Medical Center
  • Jules M. van den Bosch
    • Department of PulmonologySt. Antonius Hospital Nieuwegein
  • Henk J. Ruven
    • Department of Clinical ChemistrySt. Antonius Hospital Nieuwegein
  • Heleen van Velzen-Blad
    • Department of Medical Microbiology and ImmunologySt. Antonius Hospital Nieuwegein
  • Jan C. Grutters
    • Department of PulmonologySt. Antonius Hospital Nieuwegein
Original Article

DOI: 10.1007/s00259-009-1097-x

Cite this article as:
Keijsers, R.G., Verzijlbergen, F.J., Oyen, W.J. et al. Eur J Nucl Med Mol Imaging (2009) 36: 1131. doi:10.1007/s00259-009-1097-x

Abstract

Purpose

Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. 18F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of 18F-FDG PET, genotype-corrected ACE and sIL-2R in active sarcoidosis as well as their correlation.

Methods

This retrospective study included 36 newly diagnosed, symptomatic sarcoidosis patients. ACE and sIL-2R levels were simultaneously obtained within 4 weeks of 18F-FDG PET. ACE was corrected for genotype and expressed as Z-score. 18F-FDG PET was visually evaluated and scored as positive or negative. Maximum and average standardized uptake values (SUVmax and SUVavg) were compared with ACE and sIL-2R.

Results

18F-FDG PET was found positive in 34 of 36 patients (94%). Thirteen patients (36%) showed an increased ACE with the highest sensitivity found in patients with the I/I genotype (67%). Seventeen patients (47%) showed an increased sIL-2R. No correlation was found between SUV and ACE or sIL-2R. Increased ACE and sIL-2R correlated with a positive 18F-FDG PET in 12 patients (92%) and 16 patients (94%), respectively.

Conclusion

18F-FDG PET is a very sensitive technique to assess active sarcoidosis, in contrast with ACE and sIL-2R, suggesting a pivotal role for 18F-FDG PET in future sarcoidosis assessment.

Keywords

18F-FDG PETAngiotensin-converting enzymeSoluble interleukin-2 receptorSarcoidosis

Copyright information

© Springer-Verlag 2009