European Journal of Nuclear Medicine and Molecular Imaging

, Volume 35, Issue 12, pp 2304–2319

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

  • Fabien Chauveau
  • Hervé Boutin
  • Nadja Van Camp
  • Frédéric Dollé
  • Bertrand Tavitian
Review Article

DOI: 10.1007/s00259-008-0908-9

Cite this article as:
Chauveau, F., Boutin, H., Van Camp, N. et al. Eur J Nucl Med Mol Imaging (2008) 35: 2304. doi:10.1007/s00259-008-0908-9

Abstract

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents.

Keywords

NeuroinflammationPET[11C]PK11195Peripheral benzodiazepine receptor (PBR)Translocator protein 18kDa (TSPO)

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Fabien Chauveau
    • 1
    • 2
  • Hervé Boutin
    • 3
  • Nadja Van Camp
    • 1
    • 2
  • Frédéric Dollé
    • 1
  • Bertrand Tavitian
    • 1
    • 2
  1. 1.CEA, Institut d’Imagerie BioMédicaleService Hospitalier Frédéric Joliot, Laboratoire d’Imagerie Moléculaire ExpérimentaleOrsayFrance
  2. 2.INSERM, U803OrsayFrance
  3. 3.Faculty of Life SciencesUniversity of ManchesterManchesterUK