European Journal of Nuclear Medicine and Molecular Imaging

, Volume 35, Supplement 1, pp 12–24

A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer’s disease


    • Department of Nuclear MedicineTechnische Universität
    • Nuklearmedizinische Klinik u. Poliklinik, Klinikum rechts der IsarTechnische Universität München
  • Christian Sorg
    • Department of Psychiatry and PsychotherapyTechnische Universität
  • Afra M. Wohlschläger
    • Departments of Neuroradiology and NeurologyTechnische Universität
  • Alexander Drzezga
    • Department of Nuclear MedicineTechnische Universität

DOI: 10.1007/s00259-007-0698-5

Cite this article as:
Wermke, M., Sorg, C., Wohlschläger, A.M. et al. Eur J Nucl Med Mol Imaging (2008) 35: 12. doi:10.1007/s00259-007-0698-5


Functional imaging methods such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) allow in vivo assessment of cerebral metabolism at rest and cerebral responses to cognitive stimuli. Activation studies with different cognitive tasks have deepened the understanding of underlying pathology leading to Alzheimer disease (AD) and how the brain reacts to and potentially compensates the imposed damage inflicted by this disease. The aim of this manuscript study was to summarize current findings of activation studies in healthy people at risk for AD, in people with mild cognitive impairment (MCI) as a possible progenitor of AD and finally in patients with manifest AD, adding recent results about impaired deactivation abilities and default mode function in AD. A new comprehensive model will be introduced integrating these heterogeneous findings and explaining their impact on cognitive performance.


ActivationDeactivationDefault modeAlzheimer’s diseaseImaging

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© Springer-Verlag 2008