European Journal of Nuclear Medicine and Molecular Imaging

, Volume 34, Issue 8, pp 1240–1253

The basal ganglia matching tools package for striatal uptake semi-quantification: description and validation


  • Piero Calvini
    • Department of PhysicsUniversity and INFN
  • Guido Rodriguez
    • Clinical Neurophysiology, Department of Endocrinological and Metabolic SciencesUniversity of Genoa
  • Fabrizio Inguglia
    • Department of Informatics and Information SciencesUniversity of Genoa
  • Alessandro Mignone
    • Nuclear Medicine DivisionOspedali Riuniti
  • Ugo Paolo Guerra
    • Nuclear Medicine DivisionOspedali Riuniti
    • Clinical Neurophysiology, Department of Endocrinological and Metabolic SciencesUniversity of Genoa
Original article

DOI: 10.1007/s00259-006-0357-2

Cite this article as:
Calvini, P., Rodriguez, G., Inguglia, F. et al. Eur J Nucl Med Mol Imaging (2007) 34: 1240. doi:10.1007/s00259-006-0357-2



To design a novel algorithm (BasGan) for automatic segmentation of striatal 123I-FP-CIT SPECT.


The BasGan algorithm is based on a high-definition, three-dimensional (3D) striatal template, derived from Talairach’s atlas. A blurred template, obtained by convolving the former with a 3D Gaussian kernel (FWHM = 10 mm), approximates striatal activity distribution. The algorithm performs translations and scale transformation on the bicommissural aligned image to set the striatal templates with standard size in an appropriate initial position. An optimization protocol automatically performs fine adjustments in the positioning of blurred templates to best match the radioactive counts, and locates an occipital ROI for background evaluation. Partial volume effect correction is included in the process of uptake computation of caudate, putamen and background. Experimental validation was carried out by means of six acquisitions of an anthropomorphic striatal phantom. The BasGan software was applied to a first set of patients with Parkinson’s disease (PD) versus patients affected by essential tremor.


A highly significant correlation was achieved between true binding potential and measured 123I activity from the phantom. 123I-FP-CIT uptake was significantly lower in all basal ganglia in the PD group versus controls with both BasGan and a conventional ROI method used for comparison, but particularly with the former. Correlations with the motor UPDRS score were far more significant with the BasGan.


The novel BasGan algorithm automatically performs the 3D segmentation of striata. Because co-registered MRI is not needed, it can be used by all nuclear medicine departments, since it is freely available on the Web.


123I-FP-CIT SPECTAutomatic VOIsParkinson’s diseaseNigrostriatal systemBasal gangliaAnthropomorphic brain phantom

Copyright information

© Springer-Verlag 2007