Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography

  • Oliver Gaemperli
  • Tiziano Schepis
  • Victor Kalff
  • Mehdi Namdar
  • Ines Valenta
  • Laurent Stefani
  • Lotus Desbiolles
  • Sebastian Leschka
  • Lars Husmann
  • Hatem Alkadhi
  • Philipp A. Kaufmann
Original article

DOI: 10.1007/s00259-006-0342-9

Cite this article as:
Gaemperli, O., Schepis, T., Kalff, V. et al. Eur J Nucl Med Mol Imaging (2007) 34: 1097. doi:10.1007/s00259-006-0342-9

Abstract

Purpose

Combining the functional information of SPECT myocardial perfusion imaging (SPECT-MPI) and the morphological information of coronary CT angiography (CTA) may allow easier evaluation of the spatial relationship between coronary stenoses and perfusion defects. The aim of the present study was the validation of a novel software solution for three-dimensional (3D) image fusion of SPECT-MPI and CTA.

Methods

SPECT-MPI with adenosine stress/rest 99mTc-tetrofosmin was fused with 64-slice CTA in 15 consecutive patients with a single perfusion defect and a single significant coronary artery stenosis (≥50% diameter stenosis). 3D fused SPECT/CT images were analysed by two independent observers with regard to superposition of the stenosed vessel onto the myocardial perfusion defect. Interobserver variability was assessed by recording the X, Y, Z coordinates for the origin of the stenosed coronary artery and the centre of the perfusion defect and measuring the distance between the two landmarks.

Results

SPECT-MPI revealed a fixed defect in seven patients, a reversible defect in five patients and a mixed defect in three patients and CTA documented a significant stenosis in the respective subtending coronary artery. 3D fused SPECT/CT images showed a match of coronary lesion and perfusion defect in each patient and the fusion process took less than 15 min. Interobserver variability was excellent for landmark detection (r = 1.00 and r = 0.99, p < 0.0001) and very good for the 3D distance between the two landmarks (r = 0.94, p < 0.001).

Conclusion

3D SPECT/CT image fusion is feasible, reproducible and allows correct superposition of SPECT segments onto cardiac CT anatomy.

Keywords

SPECT/CT fusion imagingCoronary artery diseaseCT angiographyMyocardial perfusion imaging

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Oliver Gaemperli
    • 1
  • Tiziano Schepis
    • 1
  • Victor Kalff
    • 2
  • Mehdi Namdar
    • 1
  • Ines Valenta
    • 1
  • Laurent Stefani
    • 3
  • Lotus Desbiolles
    • 4
  • Sebastian Leschka
    • 4
  • Lars Husmann
    • 4
  • Hatem Alkadhi
    • 4
  • Philipp A. Kaufmann
    • 1
    • 5
  1. 1.Nuclear Cardiology, Cardiovascular CenterUniversity Hospital ZurichZurichSwitzerland
  2. 2.Department of Nuclear MedicineAlfred HospitalMelbourneAustralia
  3. 3.GE Healthcare Bio-SciencesBuc CedexFrance
  4. 4.Institute of Diagnostic RadiologyUniversity Hospital ZurichZurichSwitzerland
  5. 5.Zurich Center for Integrative Human Physiology (ZIHP)University of ZurichZurichSwitzerland