European Journal of Nuclear Medicine and Molecular Imaging

, Volume 33, Issue 1, pp 87–92

Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy

Authors

    • Division of Nuclear Medicine, Department of RadiologyHarvard Medical School and Brigham and Women’s Hospital
  • Marie-Odile Habert
    • U678 INSERM - UPMCCHU Pitié-Salpêtrière
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière
  • Philippe Maksud
    • U678 INSERM - UPMCCHU Pitié-Salpêtrière
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière
  • Aurélie Kas
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière
  • Zoulikha Malek
    • U678 INSERM - UPMCCHU Pitié-Salpêtrière
    • Department of Nuclear MedicineCHU Pitié-Salpêtrière
  • Marie Foley Kijewski
    • Division of Nuclear Medicine, Department of RadiologyHarvard Medical School and Brigham and Women’s Hospital
  • Lucette Lacomblez
    • Fédération des Maladies du Système NerveuxCHU Pitié-Salpêtrière
    • Department of PharmacologyCHU Pitié-Salpêtrière
Short Communication

DOI: 10.1007/s00259-005-1920-y

Cite this article as:
El Fakhri, G., Habert, M., Maksud, P. et al. Eur J Nucl Med Mol Imaging (2006) 33: 87. doi:10.1007/s00259-005-1920-y

Abstract

Purpose

The purpose of this study was to investigate the feasibility and utility of dual-isotope SPECT for differential diagnosis of idiopathic Parkinson’s disease (IPD) and multiple system atrophy (MSA).

Methods

Simultaneous 99mTc-ECD/123I-FP-CIT studies were performed in nine normal controls, five IPD patients, and five MSA patients. Projections were corrected for scatter, cross-talk, and high-energy penetration, and iteratively reconstructed while correcting for patient-specific attenuation and variable collimator response. Perfusion and dopamine transporter (DAT) function were assessed using voxel-based statistical parametric mapping (SPM2) and volume of interest quantitation. DAT binding potential (BP) and asymmetry index (AI) were estimated in the putamen and caudate nucleus.

Results

Striatal BP was lower in IPD (55%) and MSA (23%) compared to normal controls (p<0.01) , and in IPD compared to MSA (p<0.05). AI was greater for IPD than for MSA and controls in both the caudate nucleus and the putamen (p<0.05). There was significantly decreased perfusion in the left and right nucleus lentiformis in MSA compared to IPD and controls (p<0.05).

Conclusion

Dual-isotope studies are both feasible in and promising for the diagnosis of parkinsonian syndromes.

Keywords

Idiopathic Parkinson’s disease Multiple system atrophy 99mTc-ECD 123I-FP-CIT Dual-isotope SPECT

Copyright information

© Springer-Verlag 2005