European Journal of Nuclear Medicine and Molecular Imaging

, Volume 32, Issue 12, pp 1392–1399

Radiotherapy planning: PET/CT scanner performances in the definition of gross tumour volume and clinical target volume

Authors

    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Gloria Rossi
    • Department of Medical PhysicsS. Lucia Hospital
  • Sergio Ancidei
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Alfonso Berbellini
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Francesca Capoccetti
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Carla Cidda
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Paola D’Avenia
    • Department of Medical PhysicsS. Lucia Hospital
  • Sara Fattori
    • Department of Medical PhysicsS. Lucia Hospital
  • Gian Carlo Montini
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Gianluca Valentini
    • Department of Nuclear Medicine, Department of OncologyS. Lucia Hospital
  • Alfredo Proietti
    • Department of RadiotherapyS. Lucia Hospital
Original Article

DOI: 10.1007/s00259-005-1845-5

Cite this article as:
Brianzoni, E., Rossi, G., Ancidei, S. et al. Eur J Nucl Med Mol Imaging (2005) 32: 1392. doi:10.1007/s00259-005-1845-5

Abstract

Purpose

Positron emission tomography is the most advanced scintigraphic imaging technology and can be employed in the planning of radiation therapy (RT). The aim of this study was to evaluate the possible role of fused images (anatomical CT and functional FDG-PET), acquired with a dedicated PET/CT scanner, in delineating gross tumour volume (GTV) and clinical target volume (CTV) in selected patients and thus in facilitating RT planning.

Methods

Twenty-eight patients were examined, 24 with lung cancer (17 non-small cell and seven small cell) and four with non-Hodgkin’s lymphoma in the head and neck region. All patients underwent a whole-body PET scan after a CT scan. The CT images provided morphological volumetric information, and in a second step, the corresponding PET images were overlaid to define the effective target volume. The images were exported off-line via an internal network to an RT simulator.

Results

Three patient were excluded from the study owing to change in the disease stage subsequent to the PET/CT study. Among the remaining 25 patients, PET significantly altered the GTV or CTV in 11 (44%) . In five of these 11 cases there was a reduction in GTV or CTV, while in six there was an increase in GTV or CTV.

Conclusion

FDG-PET is a highly sensitive imaging modality that offers better visualisation of local and locoregional tumour extension. This study confirmed that co-registration of CT data and FDG-PET images may lead to significant modifications of RT planning and patient management.

Keywords

PET/CT co-registration Radiotherapy Gross tumour volume Clinical target volume Lung cancer Head and neck cancer

Copyright information

© Springer-Verlag 2005