Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography

  • Ukihide Tateishi
  • Umio Yamaguchi
  • Kunihiko Seki
  • Takashi Terauchi
  • Yasuaki Arai
  • Tadashi Hasegawa
Original article

DOI: 10.1007/s00259-005-0044-8

Cite this article as:
Tateishi, U., Yamaguchi, U., Seki, K. et al. Eur J Nucl Med Mol Imaging (2006) 33: 683. doi:10.1007/s00259-005-0044-8
  • 187 Downloads

Abstract

Purpose

This study was conducted to investigate whether 18F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sarcomas.

Methods

Eighty-two patients clinically suspected of having a bone or soft tissue sarcoma underwent FDG PET within 1 week prior to operation and 63 patients (mean age 48 years, range 18–74 years) were enrolled in the complete analysis. We excluded 17 patients with pathologically confirmed benign tumours and two patients with uncontrolled diabetes or concomitant malignancy from data analysis. Maximum and average standardised uptake values (SUVs) of the primary lesion were compared with histological variables including tumour differentiation, the presence of necrosis, MIB-1 score, mitotic score, p53 overexpression, MIB-1 grade, mitotic grade and GLUT-1 expression.

Results

Significant correlations were found between maximal and mean SUVs and MIB-1 grade, mitotic grade, MIB-1 score, tumour differentiation and mitotic score. The mean and maximal SUVs were significantly higher in tumours with p53 overexpression than in those without p53 overexpression (p<0.0001). GLUT-1-positive tumours had significantly higher mean (6.5±4.2 vs 1.1±0.2, p=0.006) and maximal SUVs (8.8±5.4 vs 1.7±0.5, p=0.005) than the GLUT-1-negative tumours. GLUT-1 intensity correlated positively with both mean (r=0.500, p<0.0001) and maximal SUVs (r=0.509, p<0.0001). Mu ltiple linear regression analysis showed a significant correlation between maximal SUV and MIB-1 grade (p<0.0001).

Conclusion

The enhanced glucose metabolism, as determined by SUV, is a strong index of tumour grade in bone and soft tissue sarcomas.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Ukihide Tateishi
    • 1
    • 6
  • Umio Yamaguchi
    • 2
  • Kunihiko Seki
    • 3
  • Takashi Terauchi
    • 4
  • Yasuaki Arai
    • 1
  • Tadashi Hasegawa
    • 5
  1. 1.Divisions of Diagnostic RadiologyNational Cancer Center HospitalTokyoJapan
  2. 2.Orthopedic DivisionNational Cancer Center Hospital,TokyoJapan
  3. 3.Division of Clinical PathologyNational Cancer Center Hospital,TokyoJapan
  4. 4.Division of RadiologyResearch Center for Cancer Prevention and Screening, National Cancer Center,TokyoJapan
  5. 5.Department of Clinical PathologySapporo Medical University School of Medicine,SapporoJapan
  6. 6.Division of Nuclear MedicineNational Cancer Center HospitalTokyoJapan

Personalised recommendations