European Journal of Nuclear Medicine and Molecular Imaging

, Volume 32, Issue 6, pp 635–640

Limited pelvic lymphadenectomy using the sentinel lymph node procedure in patients with localised prostate carcinoma: a pilot study

  • Isabelle Brenot-Rossi
  • Cyril Bastide
  • Stephane Garcia
  • Stephane Dumas
  • Benjamin Esterni
  • Jacques Pasquier
  • Dominique Rossi
Original Article

DOI: 10.1007/s00259-004-1750-3

Cite this article as:
Brenot-Rossi, I., Bastide, C., Garcia, S. et al. Eur J Nucl Med Mol Imaging (2005) 32: 635. doi:10.1007/s00259-004-1750-3

Abstract

Purpose

The purpose of this study was to determine the potential role of the sentinel lymph node (SLN) procedure in limited lymph node dissection in patients with apparently localised prostate carcinoma.

Methods

In 27 patients with organ-confined prostate cancer, a single injection of 0.3 ml/30 MBq 99mTc-rhenium sulphur colloid was injected transrectally into the peripheral zone of each lobe of the prostate (total 0.6 ml/60 MBq) under ultrasound guidance. Two hours after injection, scintigraphy was performed. The first step in surgery was the detection and dissection of lymph nodes identified as SLNs. Then, standard lymphadenectomy was performed, consisting in a limited dissection that included all lymph nodes from the obturator fossa and along the external iliac vein. Lymphatic tissue along the hypogastric artery was not systematically removed, except in the presence of SLNs.

Results

Mean patient age was 66 years (48–77); the mean serum prostate-specific antigen value was 10.6 ng/ml. In a high proportion of patients (21/27, 77.8%) an SLN was located along the initial centimetres of the hypogastric artery. The second most frequent site of SLNs was in the obturator fossa (11/27 patients, 40.7%), followed by the external iliac area (5/27 patients, 18.5%). Four patients had lymph node metastases, all in SLNs: two in the hypogastric area and two in the obturator fossa.

Conclusion

The SLN procedure revealed the individual variability in the lymphatic drainage of the prostate. The main site of SLNs was the hypogastric area, and two of the four metastatic nodes were located at this site. A limited standard pelvic lymphadenectomy, excluding the hypogastric lymph nodes, would have missed half of the lymph node metastases in this study. A radionuclide SLN procedure could assist in the correct staging of patients with early prostate cancer, especially when performing limited lymphadenectomy.

Keywords

Sentinel lymph nodeLymphoscintigraphyLymph node dissectionProstatic carcinomaProstate cancer

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Isabelle Brenot-Rossi
    • 1
  • Cyril Bastide
    • 2
  • Stephane Garcia
    • 3
  • Stephane Dumas
    • 4
  • Benjamin Esterni
    • 5
  • Jacques Pasquier
    • 1
  • Dominique Rossi
    • 2
  1. 1.Institut Paoli-Calmettes, Regional Cancer CenterUniversité de la MéditerranéeMarseille cedex 9France
  2. 2.Department of Urology, Hospital of the University of Marseille, CHU nordUniversité de la MéditerranéeMarseilleFrance
  3. 3.Department of Pathology, Hospital of the University of Marseille, CHU nordUniversité de la MéditerranéeMarseilleFrance
  4. 4.Department of Radiology, Institut Paoli-Calmettes, Regional Cancer CenterUniversité de la MéditerranéeMarseilleFrance
  5. 5.Department of Statistics, Institut Paoli-Calmettes, Regional Cancer CenterUniversité de la MéditerranéeMarseilleFrance