Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The central neurotransmitter serotonin plays a major role in a number of neuropsychiatric disorders. However, results from post-mortem and in vivo neuroimaging studies of the influence of age on the number of presynaptic serotonin transporters (SERT) are controversial. To provide further evidence of relevance for this ongoing discussion, SERT were imaged in 22 persons without neuropsychiatric impairment using [123I]2β-carbomethoxy-3β-(iodophenyl)tropane ([123I]β-CIT) and high-resolution single-photon emission tomography (SPET). The SPET analysis method was based on magnetic resonance image co-registration in order to quantify SERT with acceptable inter- and intra-observer variability. Using this technique, we found a significant age-related decline in the thalamic/hypothalamic and midbrain/upper brainstem SERT density, which was more pronounced than that previously reported in the literature. From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies.
- Meltzer CC, Smith G, DeKosky ST, et al.. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology 1998; 18:407–430.
- Arranz B, Eriksson A, Mellerup E, et al.. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain Res 1992; 620:162–166.
- Tauscher J, Verhoeff NP, Christensen BK, et al. Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. Neuropsychopharmacology 2001; 24:522–530.
- Andersson A, Sundman I, Marcusson J. Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding. Gerontology 1992; 38:127–132.
- Pirker W, Asenbaum S, Hauk M, et al. Imaging serotonin and dopamine transporters with 123I-β-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med 2000; 41:36–44.
- van Dyck CH, Malison RT, Seibyl JP, et al. Age-related decline in central serotonin transporter availability with [123I]β-CIT SPECT. Neurobiol Aging 2000; 21:497–501.
- Kuikka JT, Tammela L, Bergström KA, et al. Effects of ageing on serotonin transporters in healthy females. Eur J Nucl Med 2001; 28:911–913.
- Dahlström M, Ahonen A, Ebeling H, et al. Elevated hypothalamic/midbrain serotonin (monoamine) transporter availability in depressive drug-naive children and adolescents. Mol Psychiatry 2000; 5:514–522.
- Müller U, Wächter T, Barthel H, et al. Striatal [123I]β-CIT SPECT and prefrontal cognitive functions in Parkinson's disease. J Neural Transm 2000; 107:303–319.
- Barthel H, Sorger D, Kühn HJ, et al. Differential alteration of the nigrostriatal dopaminergic system in Wilson's disease investigated with [123I]β-CIT and high-resolution SPET. Eur J Nucl Med 2001; 28:1656–1663.
- Talairach J, Tournoux P. Co-planar stereotactic atlas of the human brain. Stuttgart, New York: Thieme, 1988.
- Murai T, Müller U, Werheid K, et al. In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. J Neuropsychiatry Clin Neurosci 2001; 13:222–228.
- Okada T, Fujita M, Shimada S, et al. Assessment of affinities of β-CIT, β-CIT-FE, and β-CIT-FP for monoamine transporters permanently expressed in cell lines. Nucl Med Biol 1998; 25:53–58.
- Olivier B, Soudijn W, van Wijngaarden I. Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors. Prog Drug Res 2000; 54:59–119.
- Staley JK, Krishnan-Sarin S, Zoghbi S, et al. Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 2001; 41:275–284.
- Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
European Journal of Nuclear Medicine and Molecular Imaging
Volume 30, Issue 3 , pp 427-430
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Serotonin transporter
- Industry Sectors
- Author Affiliations
- A1. Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany
- A4. MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
- A3. Department of Psychiatry, Faculty of Medicine, University of Kyoto, Kyoto, Japan
- A2. Psychiatry, University Hospital, University of Leipzig, Leipzig, Germany