Is correction for age necessary in neuroimaging studies of the central serotonin transporter?

  • Swen Hesse
  • Henryk Barthel
  • Toshiya Murai
  • Ulrich Müller
  • Dominic Müller
  • Anita Seese
  • Regine Kluge
  • Osama Sabri
Short Communication

DOI: 10.1007/s00259-002-1044-6

Cite this article as:
Hesse, S., Barthel, H., Murai, T. et al. Eur J Nucl Med (2003) 30: 427. doi:10.1007/s00259-002-1044-6

Abstract

The central neurotransmitter serotonin plays a major role in a number of neuropsychiatric disorders. However, results from post-mortem and in vivo neuroimaging studies of the influence of age on the number of presynaptic serotonin transporters (SERT) are controversial. To provide further evidence of relevance for this ongoing discussion, SERT were imaged in 22 persons without neuropsychiatric impairment using [123I]2β-carbomethoxy-3β-(iodophenyl)tropane ([123I]β-CIT) and high-resolution single-photon emission tomography (SPET). The SPET analysis method was based on magnetic resonance image co-registration in order to quantify SERT with acceptable inter- and intra-observer variability. Using this technique, we found a significant age-related decline in the thalamic/hypothalamic and midbrain/upper brainstem SERT density, which was more pronounced than that previously reported in the literature. From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies.

Keywords

Serotonin transporter Age Ageing [123I]β-CIT SPET 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Swen Hesse
    • 1
  • Henryk Barthel
    • 1
    • 4
  • Toshiya Murai
    • 3
  • Ulrich Müller
    • 2
  • Dominic Müller
    • 1
  • Anita Seese
    • 1
  • Regine Kluge
    • 1
  • Osama Sabri
    • 1
  1. 1.Department of Nuclear MedicineUniversity of Leipzig LeipzigGermany
  2. 2.Psychiatry, University HospitalUniversity of LeipzigLeipzigGermany
  3. 3.Department of Psychiatry, Faculty of MedicineUniversity of KyotoKyotoJapan
  4. 4.MRC Cyclotron Unit, Imperial College School of MedicineHammersmith HospitalLondonUK

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