Molecular Imaging

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 29, Issue 3, pp 388-399

First online:

The type 2 human somatostatin receptor as a platform for reporter gene imaging

  • Kurt R. ZinnAffiliated withDepartment of Radiology, University of Alabama at Birmingham, Boshell Building, BDB 11, 1530 3rd Avenue South, Birmingham, AL 35294, USA
  • , Tandra R. ChaudhuriAffiliated withDepartment of Radiology, University of Alabama at Birmingham, Boshell Building, BDB 11, 1530 3rd Avenue South, Birmingham, AL 35294, USA

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Abstract.

The human somatostatin receptor subtype 2A (hSSTr2) is under evaluation as a reporter gene for molecular imaging applications. Two approved somatostatin analogues are already available for imaging expression of the reporter gene following delivery with adenoviral (Ad) vectors or other genetic targeting strategies. In animal models, Ad-mediated expression of hSSTr2 in subcutaneous and intraperitoneal tumors was detected by non-invasive gamma camera imaging. This review discusses the rationale and strategy for using the hSSTr2 reporter gene as a platform for imaging applications.

Imaging gene expression Reporter gene Somatostatin receptor Tumor xenograft Adenovirus