Skeletal Radiology

, Volume 42, Issue 9, pp 1317–1322

Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging

  • Shivani Ahlawat
  • Jaishri Blakeley
  • Elizabeth Montgomery
  • Rathan M. Subramaniam
  • Allan Belzberg
  • Laura M. Fayad
Case Report

DOI: 10.1007/s00256-013-1626-3

Cite this article as:
Ahlawat, S., Blakeley, J., Montgomery, E. et al. Skeletal Radiol (2013) 42: 1317. doi:10.1007/s00256-013-1626-3

Abstract

Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome characterized by the development of multiple peripheral nerve sheath tumors, the majority of which are benign neurofibromas. However, malignant peripheral nerve sheath tumors (MPNSTs) occur with a 10 % lifetime risk in patients with NF1, often developing within a neurofibroma. When clinical suspicion for an MPNST arises, imaging with FDG PET and MRI is performed to characterize a peripheral tumor for potential malignancy. In this report, we describe a patient with NF-1 who had two peripheral tumors with similar features by PET, both suspicious for MPNST, but differing features by MRI, one of which was subsequently determined to be an MPNST and the second to be a schwannoma.

Keywords

Neurofibromatosis type 1 Schwannoma Malignant peripheral nerve sheath tumor Neurofibroma 

Copyright information

© ISS 2013

Authors and Affiliations

  • Shivani Ahlawat
    • 1
  • Jaishri Blakeley
    • 2
  • Elizabeth Montgomery
    • 4
  • Rathan M. Subramaniam
    • 5
  • Allan Belzberg
    • 3
  • Laura M. Fayad
    • 6
  1. 1.The Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.The Johns Hopkins Hospital Comprehensive Neurofibromatosis Center, Department of NeurologyThe Johns Hopkins HospitalBaltimoreUSA
  3. 3.Department of NeurosurgeryThe Johns Hopkins HospitalBaltimoreUSA
  4. 4.The Johns Hopkins Hospital, Department of PathologyBaltimoreUSA
  5. 5.The Johns Hopkins Hospital, The Russell H. Morgan Department of Radiology and Radiological ScienceBaltimoreUSA
  6. 6.The Russell H. Morgan Department of Radiology and Radiological ScienceThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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