Magnetic resonance imaging for extramammary Paget’s disease: radiological and pathological correlations
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Extramammary Paget’s disease (EMPD) is a rare cutaneous neoplasm that is thought to represent intraepithelial adenocarcinoma developing in an area rich in apocrine glands. Magnetic resonance imaging (MRI) findings for this disease are not well established. We report three cases of pathologically confirmed EMPD in which MRI was performed before surgery. The lesions were widespread in the epidermis and the dermis. Lesions were sharply well enhanced on gadolinium-enhanced T1-weighted imaging and appeared hyperintense on diffusion-weighted imaging in all cases. Areas with enhancement in depth corresponded well with the pathological lesion. In addition, different malignant legions were found on the same images from MRI in two cases, indicating potential associations with other malignancies. We describe the MRI findings and their pathological correlation. MRI could be useful for preoperative evaluation of disease spread and detection of associated malignancies.
- Crocker HR. Paget’s disease affecting the scrotum and penis. Trans Pathol Soc Lond. 1889
- Lloyd J, Flanagan AM. Mammary and extramammary Paget’s disease. J Clin Pathol. 2000;53:742–9. CrossRef
- Juang GD, Lin MY, Hwang TI. Extramammary Paget’s disease of the scrotum. J Chin Med Assoc. 2011;74:325–8. CrossRef
- Lai YL, Yang WG, Tsay PK, et al. Penoscrotal extramammary Paget’s disease: a review of 33 cases in a 20-year experience. Plastic Reconstr Surg. 2003;112:1017–23. CrossRef
- Karam A, Dorigo O. Treatment outcomes in a large cohort of patients with invasive extramammary Paget’s disease. Gynecol Oncol. 2012;125:346–51. CrossRef
- Zhang N, Gong K, Zhang X, et al. Extramammary Paget’s disease of scrotum. Report of 25 cases and literature review. Urol Oncol. 2010;28:28–33. CrossRef
- Lee SJ, Choe YS, Jung HD, et al. A multicenter study on extramammary Paget’s disease in Korea. Int J Dermatol. 2011;50(5):508–15. CrossRef
- Kirkham N. Tumor and cysts of the epidermis. In: Lever’s histopathology of the skin. Tenth edition David E. Elder, Editor-in-Chief 2010, p. 838–9.
- Siesling S, Elferink MAG, Dijck JAAMV. Epidemiology and treatment of extramammary Paget disease in the Netherlands. Eur J Surg Oncol. 2007;33:5–9. CrossRef
- Pierie JP, Choudry U, Muzikansky A, et al. Prognosis and management of extramammary Paget’s disease and the association with secondary malignancies. J Am Coll Surg. 2003;196(1):45–50. CrossRef
- Shiomi T, Noguchi T, Nakayama H, et al. Clinicopathological study of invasive extramammary Paget’s disease: subgroup comparison according to invasion depth. J Eur Acad Dermatol Venereol. 2012. doi:10.1111/j.1468-3083.2012.04489.x [Epub ahead of print].
- Murata Y, Kumano K. Extramammary Paget’s disease of the genitalia with clinically clear margins can be adequately resected with 1 cm margin. Eur J Dermatol. 2005;15:168–70.
- Appert DL, Otley CC, Phillips PK, et al. Role of multiple scouting biopsies before Mohs micrographic surgery for extramammary Paget’s disease. Dermatol Surg. 2005;1417–22.
- Magnetic resonance imaging for extramammary Paget’s disease: radiological and pathological correlations
Volume 42, Issue 3 , pp 437-442
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Extramammary Paget’s disease
- Preoperative evaluation
- Associated malignancy
- Industry Sectors
- Author Affiliations
- 1. Department of Radiology, St. Luke’s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan
- 2. Department of Plastic Surgery and Reconstructive Surgery, St. Luke’s International Hospital, Tokyo, Japan
- 3. Department of Dermatology, St. Luke’s International Hospital, Tokyo, Japan
- 4. Department of Pathology, St. Luke’s International Hospital, Tokyo, Japan