Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation Authors
First Online: 06 January 2012 Received: 19 October 2011 Revised: 08 December 2011 Accepted: 13 December 2011 DOI:
Cite this article as: Brennan, C.M., Atkins, K.A., Druzgal, C.H. et al. Skeletal Radiol (2012) 41: 357. doi:10.1007/s00256-011-1350-9 Abstract
Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.
Keywords Scurvy Vitamin C Malnutrition Magnetic resonance imaging Serous atrophy Gelatinous transformation References
Brailsford JF. Some radiographic manifestations of early scurvy. Arch Dis Child. 1953;28(138):81–6.
McCann P. The incidence and value of radiological signs in scurvy. Br J Radiol. 1962;35:683–6.
Laor T, Jaramillo D. MR imaging insights into skeletal maturation: what is normal? Radiology. 2009;250(1):28–38.
Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr. 1971;24(4):432–43.
Pemberton J. Medical experiments carried out in Sheffield on conscientious objectors to military service during the 1939–45 war. Int J Epidemiol. 2006;35(3):556–8.
Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009;90(5):1252–63.
Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine. 2005;72(2):124–8.
Kato K. A critique of the roentgen signs of infantile scurvy with report of thirteen cases. Radiology. 1932;18:15.
Choi SW, Park SW, Kwon YS, et al. MR imaging in a child with scurvy: a case report. Korean J Radiol. 2007;8(5):443–7.
Karthiga S, Dubey S, Garber S, Watts R. Scurvy: MRI appearances. Rheumatology (Oxford). 2008;47(7):1109.
Bohm J. Gelatinous transformation of the bone marrow: the spectrum of underlying diseases. Am J Surg Pathol. 2000;24(1):56–65.
Kaplan P, Helms C, Dussault R, Anderson M, Major N. Musculoskeletal MRI. 2nd ed. Philadelphia: Saunders; 2001.