Case Report

Skeletal Radiology

, Volume 41, Issue 3, pp 357-360

First online:

Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation

  • Christopher M. BrennanAffiliated withDepartment of Radiology and Medical Imaging, University of Virginia Health System
  • , Kristen A. AtkinsAffiliated withDepartment of Pathology, University of Virginia Health System
  • , Colleen H. DruzgalAffiliated withDepartment of Pediatrics, University of Virginia Health System
  • , Cree M. GaskinAffiliated withDepartment of Radiology and Medical Imaging, University of Virginia Health SystemDepartment of Orthopaedic Surgery, University of Virginia Health System Email author 

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Abstract

Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.

Keywords

Scurvy Vitamin C Malnutrition Magnetic resonance imaging Serous atrophy Gelatinous transformation