Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.
- Brailsford JF. Some radiographic manifestations of early scurvy. Arch Dis Child. 1953;28(138):81–6. CrossRef
- McCann P. The incidence and value of radiological signs in scurvy. Br J Radiol. 1962;35:683–6. CrossRef
- Laor T, Jaramillo D. MR imaging insights into skeletal maturation: what is normal? Radiology. 2009;250(1):28–38. CrossRef
- Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr. 1971;24(4):432–43.
- Pemberton J. Medical experiments carried out in Sheffield on conscientious objectors to military service during the 1939–45 war. Int J Epidemiol. 2006;35(3):556–8. CrossRef
- Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009;90(5):1252–63. CrossRef
- Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine. 2005;72(2):124–8. CrossRef
- Kato K. A critique of the roentgen signs of infantile scurvy with report of thirteen cases. Radiology. 1932;18:15.
- Choi SW, Park SW, Kwon YS, et al. MR imaging in a child with scurvy: a case report. Korean J Radiol. 2007;8(5):443–7. CrossRef
- Karthiga S, Dubey S, Garber S, Watts R. Scurvy: MRI appearances. Rheumatology (Oxford). 2008;47(7):1109. CrossRef
- Bohm J. Gelatinous transformation of the bone marrow: the spectrum of underlying diseases. Am J Surg Pathol. 2000;24(1):56–65. CrossRef
- Kaplan P, Helms C, Dussault R, Anderson M, Major N. Musculoskeletal MRI. 2nd ed. Philadelphia: Saunders; 2001.
- Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation
Volume 41, Issue 3 , pp 357-360
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Vitamin C
- Magnetic resonance imaging
- Serous atrophy
- Gelatinous transformation
- Industry Sectors
- Author Affiliations
- 1. Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, 22908, USA
- 3. Department of Pathology, University of Virginia Health System, Charlottesville, VA, 22908, USA
- 4. Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, 22908, USA
- 2. Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA, 22908, USA