Growing fatty mass in the back: diagnosis of a multiple symmetric lipomatosis (Madelung’s disease) in association with chronic alcoholism
Part 2: answer
Growing fatty mass in the back: diagnosis and discussion
Multiple symmetric lipomatosis (Madelung’s disease)
Multiple symmetric lipomatosis was first described in 1888 by the German surgeon Otto Madelung . Several years later, Lanois and Bensaude described a further case series of the same entity, which is now refered to as Madelung’s disease or Lanois-Bensaude syndrome .
Most affected patients are men with a history of chronic alcoholism. Typical signs of this condition are slowly growing fatty masses around the neck, upper part of the arms, pelvis, back and the thigh. There is a predilection for people from the Mediterranean .
The pathogenesis of this syndrome is unknown. Recently published data suggest that children with similar findings might have an underlying mitochondrial dysfunction [4, 5]. However the great majority of cases of Madelung’s disease occur in men aged between 30 and 70 years with known alcoholism .
There are only a few repor ...
- Madelung OW. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir 1888;37:106–30
- Launois PE, Bensaude R. De l’adenolipomatose symetrique. Bull Mem Soc Med Hop Paris. 1898;1:298.
- Ahuja AT, King AD, Chan ES, Kew J, Lam WW, Sun PM et al. Madelung disease: distribution of cervical fat and preoperative findings at sonography, MR, and CT. AJNR Am J Neuroradiol. 1998;19:707–10.
- Kratz C, Lenard HG, Ruzicka T, Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4:63–7. CrossRef
- Shetty C, Avinash KR, Auluck A, Mupparapu M. Multiple symmetric lipomatosis (MSL) of neck in a child (Madelung’s disease): report of a rare presentation. Dentomaxillofac Radiol. 2007;36:51–4. CrossRef
- Landis MS, Etemad-Rezai R, Shetty K, Goldszmidt M. Case 143: Madelung disease. Radiology. 2009;250:951–4. CrossRef
- Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S. Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord. 2002;26:253–61. CrossRef
- Tizian C, Berger A, Vykoupil KF. Malignant degeneration in Madelung’s disease (benign lipomatosis of the neck): case report. Br J Plast Surg. 1983;36:187–9. CrossRef
- Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 2005;25:1371–95. CrossRef
- Smith PD, Stadelmann WK, Wassermann RJ, Kearney RE. Benign symmetric lipomatosis (Madelung’s disease). Ann Plast Surg. 1998;41:671–3. CrossRef
- Ampollini L, Carbognani P. Images in clinical medicine. Madelung’s disease. N Engl J Med. 2011;364:465. CrossRef
- Schreibman IR, Baker M, Amos C, McGarrity TJ. The hamartomatous polyposis syndromes: a clinical and molecular review. Am J Gastroenterol. 2005;100:476–90. CrossRef
- Gujrati M, Thomas C, Zelby A, Jensen E, Lee JM. Bannayan-Zonana syndrome: a rare autosomal dominant syndrome with multiple lipomas and hemangiomas: a case report and review of literature. Surg Neurol. 1998;50:164–8. CrossRef
- Reece PH, Wyatt M, O’Flynn P. Dercum’s disease (adiposis dolorosa). J Laryngol Otol. 1999;113:174–6.
- Growing fatty mass in the back: diagnosis of a multiple symmetric lipomatosis (Madelung’s disease) in association with chronic alcoholism
Volume 41, Issue 4 , pp 489-490
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- 1. Department of Radiology, Cantonal Hospital Winterthur, Brauerstrasse 15, 8401, Winterthur, Switzerland
- 2. Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria
- 3. Departement of Surgery, Cantonal Hospital Winterthur, Brauerstrasse 15, 8401, Winterthur, Switzerland
- 4. Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Militärstrasse 8, CH-8021, Zürich, Switzerland
- 5. Institute of Radiology and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland