Skeletal Radiology

, Volume 40, Issue 10, pp 1315–1327

Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study

  • Robert Stahl
  • Sapna K. Jain
  • Jürgen Lutz
  • Bradley T. Wyman
  • Marie-Pierre Hellio Le Graverand-Gastineau
  • Eric Vignon
  • Sharmila Majumdar
  • Thomas M. Link
Scientific Article

DOI: 10.1007/s00256-011-1156-9

Cite this article as:
Stahl, R., Jain, S.K., Lutz, J. et al. Skeletal Radiol (2011) 40: 1315. doi:10.1007/s00256-011-1156-9
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Abstract

Objective

To compare a semi-quantitative and a quantitative morphological score for assessment of early osteoarthritis (OA) evolution.

Materials and methods

3.0 T MRI of the knee was performed in 60 women, 30 with early OA (each 15 with Kellgren–Lawrence grade 2 and 3) and 30 age-matched controls at baseline and at 12 and 24 months. Pathological condition was assessed with the whole-organ magnetic resonance imaging score (WORMS). Cartilage abnormalities and bone marrow edema pattern (BMEP) were also quantified using a previously introduced morphological quantitative score. These data were correlated with changes in clinical parameters and joint space width using generalized estimation equations (GEE).

Results

At baseline, OA patients had significantly (p < 0.05) more and larger cartilage lesions and BMEP. During follow-up, cartilage lesions increased significantly (p < 0.05) in the patients compared with controls: WORMS showed progression only at the lateral patella, whereas the quantitative score revealed progression additionally at the trochlea and at the medial compartment. Both scores showed a significant (p < 0.05) increase in BMEP at the lateral femur in OA patients. In addition, quantitative scores of BMEP of the whole knee decreased significantly (p < 0.05) after 12 months and increased after 24 months in the patients, but showed an increase in controls at all follow-up examinations. Only weak correlations between structural imaging findings and clinical parameters were observed.

Conclusion

Quantitative assessment of cartilage lesions and BMEP is more sensitive to changes during the course of the disease than semi-quantitative scoring. However, structural imaging findings do not correlate well with the clinical progression of OA.

Keywords

Osteoarthritis Magnetic resonance imaging Cartilage lesion Bone marrow edema pattern Follow-up Lesion size 

Copyright information

© ISS 2011

Authors and Affiliations

  • Robert Stahl
    • 1
    • 2
  • Sapna K. Jain
    • 1
  • Jürgen Lutz
    • 3
  • Bradley T. Wyman
    • 4
  • Marie-Pierre Hellio Le Graverand-Gastineau
    • 4
  • Eric Vignon
    • 5
  • Sharmila Majumdar
    • 1
  • Thomas M. Link
    • 1
  1. 1.Department of RadiologyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Department of Clinical Radiology, University Hospitals, Campus GrosshadernLudwig Maximilians University of MunichMunichGermany
  3. 3.Department of Neuroradiology, University Hospitals, Campus GrosshadernLudwig Maximilians University of MunichMunichGermany
  4. 4.Pfizer Inc.GrotonUSA
  5. 5.Claude Bernard University Lyon ILyonFrance

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