Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study
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To compare a semi-quantitative and a quantitative morphological score for assessment of early osteoarthritis (OA) evolution.
Materials and methods
3.0 T MRI of the knee was performed in 60 women, 30 with early OA (each 15 with Kellgren–Lawrence grade 2 and 3) and 30 age-matched controls at baseline and at 12 and 24 months. Pathological condition was assessed with the whole-organ magnetic resonance imaging score (WORMS). Cartilage abnormalities and bone marrow edema pattern (BMEP) were also quantified using a previously introduced morphological quantitative score. These data were correlated with changes in clinical parameters and joint space width using generalized estimation equations (GEE).
At baseline, OA patients had significantly (p < 0.05) more and larger cartilage lesions and BMEP. During follow-up, cartilage lesions increased significantly (p < 0.05) in the patients compared with controls: WORMS showed progression only at the lateral patella, whereas the quantitative score revealed progression additionally at the trochlea and at the medial compartment. Both scores showed a significant (p < 0.05) increase in BMEP at the lateral femur in OA patients. In addition, quantitative scores of BMEP of the whole knee decreased significantly (p < 0.05) after 12 months and increased after 24 months in the patients, but showed an increase in controls at all follow-up examinations. Only weak correlations between structural imaging findings and clinical parameters were observed.
Quantitative assessment of cartilage lesions and BMEP is more sensitive to changes during the course of the disease than semi-quantitative scoring. However, structural imaging findings do not correlate well with the clinical progression of OA.
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- Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study
Volume 40, Issue 10 , pp 1315-1327
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- Magnetic resonance imaging
- Cartilage lesion
- Bone marrow edema pattern
- Lesion size
- Industry Sectors
- Author Affiliations
- 1. Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107–0946, USA
- 2. Department of Clinical Radiology, University Hospitals, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377, Munich, Germany
- 3. Department of Neuroradiology, University Hospitals, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377, Munich, Germany
- 4. Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA
- 5. Claude Bernard University Lyon I, 69495, Lyon, France