Skeletal Radiology

, Volume 40, Issue 3, pp 295–302

Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging

  • Ming Gang Su
  • Rong Tian
  • Qiu Ping Fan
  • Ye Tian
  • Fang Lan Li
  • Lin Li
  • An Ren Kuang
  • John Howard Miller
Scientific Article

DOI: 10.1007/s00256-010-0999-9

Cite this article as:
Su, M.G., Tian, R., Fan, Q.P. et al. Skeletal Radiol (2011) 40: 295. doi:10.1007/s00256-010-0999-9

Abstract

Purpose

Fibrous dysplasia of bone (FDB) reveals intense 18F-FDG uptake mimicking metastases on 18F-FDG PET/CT. We reviewed sites of FDB revealed by 18F-FDG PET/CT imaging to allow identification of this abnormality.

Materials and Methods

Eleven patients (7 male, 4 female, aged 16–78 years) were evaluated after 55 MBq (0.15 mCi)/kg 18F-FDG utilizing a 16-slice multiple detector CT (MDCT) whole-body PET scanner, with LOR algorithm 3D reconstruction. One- and 2-h imaging was performed in 9 patients. Standard uptake value (SUV) for each lesion, on early and delayed imaging, was calculated. Lesions were confirmed in 6 patients by biopsy. The PET images correlated with MDCT to establish the imaging characteristics.

Results

Solitary lesions were found in 4 patients, two lesions in 1 patient, and in 6 patients there were multiple bone lesions. The SUVearly ranged from 1.23 to 9.64 with an average of 3.76 ± 2.40. The SUVdelayed ranged from 1.76 to 11.42 with an average of 4.51 ± 3.07. The SUVdelayed decreased or increased slightly (−31% to 5%) in 6 of our patients, and increased significantly (11% to 39%) in 3. There was a negative correlation between SUVs and age, as well as the number of affected bones.

Conclusions

In our study, FDB had wide skeletal distribution with variability of 18F-FDG uptake and CT appearance. SUV in the delayed stage was seen to either decrease or increase on dual-time 18F-FDG PET scanning. It is very important to recognize the characteristics of this skeletal dysplasia to allow differentiation from skeletal metastasis.

Keywords

18F-FDGPET/CTChildren and adultsSkeletal dysplasiaFibrous dysplasia

Copyright information

© ISS 2010

Authors and Affiliations

  • Ming Gang Su
    • 1
  • Rong Tian
    • 1
  • Qiu Ping Fan
    • 1
  • Ye Tian
    • 1
  • Fang Lan Li
    • 1
  • Lin Li
    • 1
  • An Ren Kuang
    • 1
  • John Howard Miller
    • 2
  1. 1.National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of MedicineChengduPeople’s Republic of China
  2. 2.Division of Pediatric Radiology, Department of RadiologyLoma Linda University School of MedicineLoma LindaUSA