Skeletal Radiology

, Volume 40, Issue 3, pp 295–302

Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging

Authors

  • Ming Gang Su
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • Rong Tian
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • Qiu Ping Fan
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • Ye Tian
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • Fang Lan Li
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • Lin Li
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
  • An Ren Kuang
    • National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China HospitalSichuan University School of Medicine
    • Division of Pediatric Radiology, Department of RadiologyLoma Linda University School of Medicine
Scientific Article

DOI: 10.1007/s00256-010-0999-9

Cite this article as:
Su, M.G., Tian, R., Fan, Q.P. et al. Skeletal Radiol (2011) 40: 295. doi:10.1007/s00256-010-0999-9

Abstract

Purpose

Fibrous dysplasia of bone (FDB) reveals intense 18F-FDG uptake mimicking metastases on 18F-FDG PET/CT. We reviewed sites of FDB revealed by 18F-FDG PET/CT imaging to allow identification of this abnormality.

Materials and Methods

Eleven patients (7 male, 4 female, aged 16–78 years) were evaluated after 55 MBq (0.15 mCi)/kg 18F-FDG utilizing a 16-slice multiple detector CT (MDCT) whole-body PET scanner, with LOR algorithm 3D reconstruction. One- and 2-h imaging was performed in 9 patients. Standard uptake value (SUV) for each lesion, on early and delayed imaging, was calculated. Lesions were confirmed in 6 patients by biopsy. The PET images correlated with MDCT to establish the imaging characteristics.

Results

Solitary lesions were found in 4 patients, two lesions in 1 patient, and in 6 patients there were multiple bone lesions. The SUVearly ranged from 1.23 to 9.64 with an average of 3.76 ± 2.40. The SUVdelayed ranged from 1.76 to 11.42 with an average of 4.51 ± 3.07. The SUVdelayed decreased or increased slightly (−31% to 5%) in 6 of our patients, and increased significantly (11% to 39%) in 3. There was a negative correlation between SUVs and age, as well as the number of affected bones.

Conclusions

In our study, FDB had wide skeletal distribution with variability of 18F-FDG uptake and CT appearance. SUV in the delayed stage was seen to either decrease or increase on dual-time 18F-FDG PET scanning. It is very important to recognize the characteristics of this skeletal dysplasia to allow differentiation from skeletal metastasis.

Keywords

18F-FDGPET/CTChildren and adultsSkeletal dysplasiaFibrous dysplasia

Copyright information

© ISS 2010