Skeletal Radiology

, Volume 38, Issue 5, pp 425–436

Bone marrow edema syndrome

  • Anastasios V. Korompilias
  • Apostolos H. Karantanas
  • Marios G. Lykissas
  • Alexandros E. Beris
Review Article

DOI: 10.1007/s00256-008-0529-1

Cite this article as:
Korompilias, A.V., Karantanas, A.H., Lykissas, M.G. et al. Skeletal Radiol (2009) 38: 425. doi:10.1007/s00256-008-0529-1

Abstract

Bone marrow edema syndrome (BMES) refers to transient clinical conditions with unknown pathogenic mechanism, such as transient osteoporosis of the hip (TOH), regional migratory osteoporosis (RMO), and reflex sympathetic dystrophy (RSD). BMES is primarily characterized by bone marrow edema (BME) pattern. The disease mainly affects the hip, the knee, and the ankle of middle-aged males. Many hypotheses have been proposed to explain the pathogenesis of the disease. Unfortunately, the etiology of BMES remains obscure. The hallmark that separates BMES from other conditions presented with BME pattern is its self-limited nature. Laboratory tests usually do not contribute to the diagnosis. Histological examination of the lesion is unnecessary. Plain radiographs may reveal regional osseous demineralization. Magnetic resonance imaging is mainly used for the early diagnosis and monitoring the progression of the disease. Early differentiation from other aggressive conditions with long-term sequelae is essential in order to avoid unnecessary treatment. Clinical entities, such as TOH, RMO, and RSD are spontaneously resolving, and surgical treatment is not needed. On the other hand, early differential diagnosis and surgical treatment in case of osteonecrosis is of crucial importance.

Keywords

Bone marrow edema Regional migratory osteoporosis Transient osteoporosis Reflex sympathetic dystrophy Osteonecrosis MR imaging/diagnosis 

Copyright information

© ISS 2008

Authors and Affiliations

  • Anastasios V. Korompilias
    • 1
  • Apostolos H. Karantanas
    • 2
  • Marios G. Lykissas
    • 1
  • Alexandros E. Beris
    • 1
  1. 1.Department of Orthopaedic Surgery, School of MedicineUniversity of IoanninaIoanninaGreece
  2. 2.Department of RadiologyUniversity of Crete School of MedicineHeraklionGreece

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