Skeletal Radiology

, Volume 37, Issue 5, pp 465–467

Hyperplastic callus formation in osteogenesis imperfecta type V: follow-up of three generations over ten years

Authors

  • Moira S. Cheung
    • Genetics UnitShriners Hospital for Children and McGill University
  • E. Michel Azouz
    • Genetics UnitShriners Hospital for Children and McGill University
  • Francis H. Glorieux
    • Genetics UnitShriners Hospital for Children and McGill University
    • Genetics UnitShriners Hospital for Children and McGill University
    • Genetics UnitShriners Hospital for Children
Case Report

DOI: 10.1007/s00256-007-0441-0

Cite this article as:
Cheung, M.S., Azouz, E.M., Glorieux, F.H. et al. Skeletal Radiol (2008) 37: 465. doi:10.1007/s00256-007-0441-0

Abstract

Hyperplastic callus (HPC) formation is a prominent feature of osteogenesis imperfecta (OI) type V; however, little is known about its long-term outcome. In this case report we describe the occurrence, appearance and course of a femoral HPC in a patient with OI type V during 10 years of follow-up. Radiographs of HPC in this child were compared and contrasted with HPC formation in the femur of his father and paternal grandfather, who also were affected with OI type V. This case report makes it clear that HPC can lead to significant morbidity, not only in the acute phase but also long term as a result of residual alteration in bone architecture.

Keywords

FracturesGenetic disorderHyperplastic callusOsteogenesis imperfectaRadiographs

Copyright information

© ISS 2008