Applied Microbiology and Biotechnology

, Volume 87, Issue 4, pp 1281–1289

Biotechnological production and applications of N-acetyl-d-neuraminic acid: current state and perspectives


DOI: 10.1007/s00253-010-2700-6

Cite this article as:
Tao, F., Zhang, Y., Ma, C. et al. Appl Microbiol Biotechnol (2010) 87: 1281. doi:10.1007/s00253-010-2700-6


N-Acetyl-d-neuraminic acid (Neu5Ac) and its derivates are a very important group of biomolecules because these sugars occupy the terminal positions in numerous macromolecules, such as the glycans of glycoproteins, and are involved in many biological and pathological phenomena. The synthesis and applications of Neu5Ac are attracting much interest due to the potential applications of this compound in the pharmaceutical industry, such as in the synthesis of the anti-flu drug zanamivir. In this review article, we discuss existing knowledge on the biotechnological production and applications of Neu5Ac and also propose some guidelines for future studies.


N-Acetyl-d-neuraminic acidSialic acidBiocatalysisApplication

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Microbial TechnologyShandong UniversityJinanPeople’s Republic of China