Applied Microbiology and Biotechnology

, Volume 87, Issue 2, pp 401–410

Recombinant immunotherapeutics: current state and perspectives regarding the feasibility and market

Mini-Review

DOI: 10.1007/s00253-010-2590-7

Cite this article as:
Huang, CJ., Lowe, A.J. & Batt, C.A. Appl Microbiol Biotechnol (2010) 87: 401. doi:10.1007/s00253-010-2590-7

Abstract

Recombinant immunotherapeutics are important biologics for the treatment and prevention of various diseases. Immunotherapy can be divided into two categories, passive and active. For passive immunotherapy, the successes of antibody and cytokine therapeutics represent a promising future and opportunities for improvements. Efforts, such as cell engineering, antibody engineering, human-like glycosylation in yeast, and Fab fragment development, have led the way to improve antibody efficacy while decreasing its high manufacturing costs. Both new cytokines and currently used cytokines have demonstrated therapeutic effects for different indications. As for active immunotherapy, recently approved HPV vaccines have encouraged the development of preventative vaccines for other infectious diseases. Immunogenic antigens of pathogenic bacteria can now be identified by genomic means (reverse vaccinology). Due to the recent outbreaks of pandemic H1N1 influenza virus, recombinant influenza vaccines using virus-like particles and other antigens have also been engineered in several different recombinant systems. However, limitations are found in existing immunotherapeutics for cancer treatment, and recent development of therapeutic cancer vaccines such as MAGE-A3 and NY-ESO-1 may provide alternative therapeutic strategy.

Keywords

Recombinant immunotherapeutics Immunotherapy Antibodies Cytokines Preventative recombinant vaccines Therapeutic cancer vaccine 

Supplementary material

253_2010_2590_MOESM1_ESM.doc (78 kb)
Supplement Table 1A list of commercialized immunotherapeutics and some developmental cancer vaccines in the USa (DOC 78 kb)

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Field of Microbiology, 317 Stocking HallCornell UniversityIthacaUSA