Applied Microbiology and Biotechnology

, Volume 87, Issue 1, pp 9–19

Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases

  • Chang-Su Park
  • Mi-Hyun Yoo
  • Kyeong-Hwan Noh
  • Deok-Kun Oh
Mini-Review

DOI: 10.1007/s00253-010-2567-6

Cite this article as:
Park, C., Yoo, M., Noh, K. et al. Appl Microbiol Biotechnol (2010) 87: 9. doi:10.1007/s00253-010-2567-6

Abstract

Ginsenosides are the principal components responsible for the pharmaceutical activities of ginseng. The minor ginsenosides, which are also pharmaceutically active, can be produced via the hydrolysis of the sugar moieties in the major ginsenosides using acid hydrolytic, heating, microbial, and enzymatic transformation techniques. The enzymatic method has a profound potential for ginsenoside transformation, owing to its high specificity, yield, and productivity, and this method is increasingly being recognized as a useful tool in structural modification and metabolism studies. In this article, the transformation methods of ginsenosides, the characterization of microbial glycosidases with ginsenoside hydrolyzing activities, and the enzymatic production of minor ginsenosides are reviewed. Moreover, the conversions of ginsenosides using cell extracts from food microorganisms and recombinant thermostable β-d-glycosidases are proposed as feasible methods for use in industrial processes.

Keywords

GinsenosidesGinsenoside hydrolyzing enzymeGinsenoside biotransformationGlycosidaseEnzyme characterization

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Chang-Su Park
    • 1
  • Mi-Hyun Yoo
    • 1
  • Kyeong-Hwan Noh
    • 1
  • Deok-Kun Oh
    • 1
  1. 1.Department of Bioscience and BiotechnologyKonkuk UniversitySeoulRepublic of Korea