Applied Microbiology and Biotechnology

, Volume 86, Issue 5, pp 1387–1397

Use of sustainable chemistry to produce an acyl amino acid surfactant

  • Gabriel O. Reznik
  • Prashanth Vishwanath
  • Michelle A. Pynn
  • Joy M. Sitnik
  • Jeffrey J. Todd
  • Jun Wu
  • Yan Jiang
  • Brendan G. Keenan
  • Andrew B. Castle
  • Richard F. Haskell
  • Temple F. Smith
  • Ponisseril Somasundaran
  • Kevin A. Jarrell
Biotechnological Products and Process Engineering

DOI: 10.1007/s00253-009-2431-8

Cite this article as:
Reznik, G.O., Vishwanath, P., Pynn, M.A. et al. Appl Microbiol Biotechnol (2010) 86: 1387. doi:10.1007/s00253-009-2431-8

Abstract

Surfactants find wide commercial use as foaming agents, emulsifiers, and dispersants. Currently, surfactants are produced from petroleum, or from seed oils such as palm or coconut oil. Due to concerns with CO2 emissions and the need to protect rainforests, there is a growing necessity to manufacture these chemicals using sustainable resources In this report, we describe the engineering of a native nonribosomal peptide synthetase pathway (i.e., surfactin synthetase), to generate a Bacillus strain that synthesizes a highly water-soluble acyl amino acid surfactant, rather than the water insoluble lipopeptide surfactin. This novel product has a lower CMC and higher water solubility than myristoyl glutamate, a commercial surfactant. This surfactant is produced by fermentation of cellulosic carbohydrate as feedstock. This method of surfactant production provides an approach to sustainable manufacturing of new surfactants.

Keywords

SurfactantNRPS engineeringSustainable chemistryAcyl amino acidCombinatorial synthesis

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Gabriel O. Reznik
    • 1
  • Prashanth Vishwanath
    • 1
  • Michelle A. Pynn
    • 1
  • Joy M. Sitnik
    • 1
  • Jeffrey J. Todd
    • 1
  • Jun Wu
    • 2
  • Yan Jiang
    • 1
  • Brendan G. Keenan
    • 1
  • Andrew B. Castle
    • 1
  • Richard F. Haskell
    • 1
  • Temple F. Smith
    • 1
  • Ponisseril Somasundaran
    • 2
  • Kevin A. Jarrell
    • 1
  1. 1.Modular Genetics, Inc.CambridgeUSA
  2. 2.I/UC Research Center for Novel SurfactantsColumbia UniversityNew YorkUSA