Mini-Review

Applied Microbiology and Biotechnology

, Volume 77, Issue 2, pp 245-255

γ-Cyclodextrin: a review on enzymatic production and applications

  • Zhaofeng LiAffiliated withKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University
  • , Miao WangAffiliated withKey Laboratory of Food Science and Safety, Ministry of Education, School of Food Science and Technology, Jiangnan University
  • , Feng WangAffiliated withKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University
  • , Zhengbiao GuAffiliated withKey Laboratory of Food Science and Safety, Ministry of Education, School of Food Science and Technology, Jiangnan University
  • , Guocheng DuAffiliated withKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University
  • , Jing WuAffiliated withState Key Laboratory of Food Science and Technology, Jiangnan UniversitySchool of Biotechnology, Jiangnan University Email author 
  • , Jian ChenAffiliated withState Key Laboratory of Food Science and Technology, Jiangnan UniversitySchool of Biotechnology, Jiangnan University Email author 

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Abstract

Cyclodextrins are cyclic α-1,4-glucans that are produced from starch or starch derivates using cyclodextrin glycosyltransferase (CGTase). The most common forms are α-, β-, and γ-cyclodextrins. This mini-review focuses on the enzymatic production, unique properties, and applications of γ-cyclodextrin as well as its difference with α- and β-cyclodextrins. As all known wild-type CGTases produce a mixture of α-, β-, and γ-cyclodextrins, the obtaining of a CGTase predominantly producing γ-cyclodextrin is discussed. Recently, more economic production processes for γ-cyclodextrin have been developed using improved γ-CGTases and appropriate complexing agents. Compared with α- and β-cyclodextrins, γ-cyclodextrin has a larger internal cavity, higher water solubility, and more bioavailability, so it has wider applications in many industries, especially in the food and pharmaceutical industries.

Keywords

Gamma-Cyclodextrin Cyclodextrin glycosyltransferase Enzymatic production Application Property