Applied Microbiology and Biotechnology

, Volume 76, Issue 5, pp 1137–1144

Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66

  • JianLan You
  • XiaoLi Xue
  • LiXiang Cao
  • Xin Lu
  • Jian Wang
  • LiXin Zhang
  • ShiNing Zhou
Applied Microbial and Cell Physiology

DOI: 10.1007/s00253-007-1074-x

Cite this article as:
You, J., Xue, X., Cao, L. et al. Appl Microbiol Biotechnol (2007) 76: 1137. doi:10.1007/s00253-007-1074-x

Abstract

China remains by far the largest aquaculture producer in the world. However, biofilms formed by pathogenic Vibrio strains pose serious problems to marine aquaculture. To provide a strategy for biofilm prevention, control, and eradication, extracts from 88 marine actinomycetes were screened. Thirty-five inhibited the biofilm formation of Vibrio harveyi, Vibrio vulnificus, and Vibrio anguillarum at a concentration of 2.5% (v/v). Thirty-three of the actinomycete extracts dispersed the mature biofilm. Six extracts inhibited the quorum-sensing system of V. harveyi by attenuating the signal molecules N-acylated homoserine lactones’ activity. Strain A66, which was identified as Steptomyces albus, both attenuated the biofilms and inhibited their quorum-sensing system. It is suggested that strain A66 is a promising candidate to be used in future marine aquaculture.

Keywords

Vibrio biofilm Quorum sensing Biocontrol 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • JianLan You
    • 1
    • 2
  • XiaoLi Xue
    • 1
  • LiXiang Cao
    • 1
  • Xin Lu
    • 1
  • Jian Wang
    • 3
    • 4
  • LiXin Zhang
    • 2
    • 3
    • 4
    • 5
  • ShiNing Zhou
    • 1
  1. 1.State Key Laboratory for Biocontrol, College of Life SciencesSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Guangzhou Institute of Biomedicine and HealthChinese Academy of SciencesGuangzhouPeople’s Republic of China
  3. 3.Institute of MicrobiologyChinese Academy of Sciences (CAS)BeijingPeople’s Republic of China
  4. 4.South China Sea Institute of OceanologyCASGuangzhouPeople’s Republic of China
  5. 5.SynerZ PharmaceuticalsLexingtonUSA