Applied Microbiology and Biotechnology

, Volume 69, Issue 3, pp 237–244

Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications

Mini-Review

DOI: 10.1007/s00253-005-0156-x

Cite this article as:
Witczak, Z.J. & Culhane, J.M. Appl Microbiol Biotechnol (2005) 69: 237. doi:10.1007/s00253-005-0156-x

Abstract

Thiosugars, containing a sulfur atom as heteroatom or a disaccharide linked via a sulfur bridge, possess unique physicochemical properties such as water solubility, which differs from conventional functionalized monosaccharides. The differences in biological activities between thiosugars and their oxygen analogs depend on geometric, conformational, and flexibility differences. They depend also on their electronic differences, the sulfide function being less electronegative and more polarizable than the ethereal moiety. Many functionalized thiosugars occur naturally and are potential targets for the development of carbohydrate-based therapeutics. Among the few new examples of the potential new targets are salacinol and kotalanol, tagetitoxin, thiolactomycin and analogues, mycothiol and analogues, and S-nitrosothiols. These new developments and representative examples of functionalized thiosugar prototypes as potential new targets are presented in this mini review.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Pharmaceutical SciencesNesbitt School of Pharmacy, Wilkes UniversityWilkes-BarreUSA