Immunogenetics

, Volume 53, Issue 4, pp 296–306

Vanin genes are clustered (human 6q22–24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes

  • Florent Martin
  • Fabrice Malergue
  • Giuseppina Pitari
  • Jean Philippe
  • Samantha Philips
  • Claude Chabret
  • Samuel Granjeaud
  • Marie Mattei
  • Andrew J. Mungall
  • Philippe Naquet
  • Franck Galland
Original Paper

DOI: 10.1007/s002510100327

Cite this article as:
Martin, F., Malergue, F., Pitari, G. et al. Immunogenetics (2001) 53: 296. doi:10.1007/s002510100327

Abstract.

The mouse Vanin-1 molecule plays a role in thymic reconstitution following damage by irradiation. We recently demonstrated that it is a membrane pantetheinase (EC 3.56.1.–). This molecule is the prototypic member of a larger Vanin family encoded by at least two mouse (Vanin-1 and Vanin-3) and three human (VNN1, VNN2, VNN3) orthologous genes. We now report (1) the structural characterization of the human and mouse Vanin genes and their organization in clusters on the 6q22–24 and 10A2B1 chromosomes, respectively; (2) identification of the human VNN3 gene and the demonstration that the mouse Vanin-3 molecule is secreted by cells, and (3) that the Vanin genes encode different isoforms of the mammalian pantetheinase activity. Thus, the Vanin family represents a novel class of secreted or membrane-associated ectoenzymes. We discuss here their possible role in processes pertaining to tissue repair in the context of oxidative stress.

Gene cluster Human Chromosome 6 Ectoenzymes Pantetheinase Oxidative stress Tissue repair

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Florent Martin
    • 1
  • Fabrice Malergue
    • 1
  • Giuseppina Pitari
    • 2
  • Jean Philippe
    • 1
  • Samantha Philips
    • 3
  • Claude Chabret
    • 1
  • Samuel Granjeaud
    • 1
  • Marie Mattei
    • 4
  • Andrew J. Mungall
    • 3
  • Philippe Naquet
    • 1
  • Franck Galland
    • 1
  1. 1.Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Parc Scientifique de Luminy, case 906, 13288 Marseille cedex 09, France
  2. 2.Dipartimento di Biologia di Base e Applicata, Università di L'Aquilà, via Vetoio 67010 Coppito-L'Aquilà, Italy
  3. 3.The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
  4. 4.Unité de Génétique Médicale et Développement, INSERM U406, Hôpital de la Timone, 13385 Marseille cedex 05, France