Immunogenetics

, Volume 53, Issue 2, pp 87–94

PAProC: a prediction algorithm for proteasomal cleavages available on the WWW

  • Alexander Konrad Nussbaum
  • Christina Kuttler
  • Karl-Peter Hadeler
  • Hans-Georg Rammensee
  • Hansjörg Schild
Original Paper

DOI: 10.1007/s002510100300

Cite this article as:
Nussbaum, A., Kuttler, C., Hadeler, K. et al. Immunogenetics (2001) 53: 87. doi:10.1007/s002510100300

Abstract.

The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data. It will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes. Likewise, in cases in which proteasomal protein degradation has been indicated in disease, PAProC can be used to assess the general cleavability of disease-linked proteins. On its web site (http://www.paproc.de), background information and hyperlinks are provided for the user (e.g., to SYFPEITHI, the database for the prediction of MHC I ligands).

Proteasome Cleavage prediction Algorithm MHC CTL epitope

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Alexander Konrad Nussbaum
    • 1
  • Christina Kuttler
    • 2
  • Karl-Peter Hadeler
    • 2
  • Hans-Georg Rammensee
    • 1
  • Hansjörg Schild
    • 1
  1. 1.Universität Tübingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, 72076 Tübingen, Germany
  2. 2.Universität Tübingen, Biomathematik, Auf der Morgenstelle 10, 72076 Tübingen, Germany