Immunogenetics

, Volume 49, Issue 7, pp 605–612

Population study of allelic diversity in the human MHC class I-related MIC-A gene

Authors

  • E. W. Petersdorf
    • Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109-1024, USA e-mail: epetersd@fhcrc.org, Tel.: +1-206-6675244, Fax: +1-206-6675255
  • Klaus B. Shuler
    • Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109-1024, USA e-mail: epetersd@fhcrc.org, Tel.: +1-206-6675244, Fax: +1-206-6675255
  • Gary M. Longton
    • Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109-1024, USA e-mail: epetersd@fhcrc.org, Tel.: +1-206-6675244, Fax: +1-206-6675255
  • Thomas Spies
    • Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109-1024, USA e-mail: epetersd@fhcrc.org, Tel.: +1-206-6675244, Fax: +1-206-6675255
  • John A. Hansen
    • Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109-1024, USA e-mail: epetersd@fhcrc.org, Tel.: +1-206-6675244, Fax: +1-206-6675255
ORIGINAL PAPER

DOI: 10.1007/s002510050655

Cite this article as:
Petersdorf, E., Shuler, K., Longton, G. et al. Immunogenetics (1999) 49: 605. doi:10.1007/s002510050655

Abstract

 The polymorphism of major histocompatibility complex (MHC) class I HLA-A, -B, and -C molecules may have evolved through pathogen-driven selection of alleles with diverse peptide-binding specificities. Two MHC-encoded molecules that are distantly related to class I, MIC-A and MIC-B, do not function in the presentation of pathogen-derived peptides to T cells with αβ T-cell receptors (TCRs), but are broadly recognized by intraepithelial T cells with γδ TCRs. However, both MIC-A and MIC-B are polymorphic, displaying an unusual distribution of a number of variant amino acids in their extracellular α1, α2, and α3 domains. In order to further define the polymorphism of MIC-A, we examined its alleles among 275 individuals with common and rare HLA genotypes. Of 16 previously defined alleles, 12 were confirmed and 5 new alleles were identified. A two-by-two analysis of MIC-A and HLA-B alleles uncovered a number of statistically significant associations. These results confirm and extend previous knowledge on the polymorphism of MIC-A. The strong positive linkage of certain MIC-A and HLA-B alleles may have implications for studies related to MHC-associated diseases and transplantation.

Key words MIC-A geneAllelic diversityAllelic frequenciesHLA-BLinkage disequilibrium

Copyright information

© Springer-Verlag Berlin Heidelberg 1999