Immunogenetics

, Volume 51, Issue 4, pp 373–382

BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse

Authors

  • M. Stammers
    • Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK e-mail: beck@sanger.ac.uk Tel.: +44-1223-494952 Fax: +44-1223-494919
  • L. Rowen
    • Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195-7730, USA
  • D. Rhodes
    • Immunology, Department of Pathology, Tennis Court Road, Cambridge, CB2 1PQ, UK
  • J. Trowsdale
    • Immunology, Department of Pathology, Tennis Court Road, Cambridge, CB2 1PQ, UK
  • S. Beck
    • Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK e-mail: beck@sanger.ac.uk Tel.: +44-1223-494952 Fax: +44-1223-494919
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DOI: 10.1007/s002510050633

Cite this article as:
Stammers, M., Rowen, L., Rhodes, D. et al. Immunogenetics (2000) 51: 373. doi:10.1007/s002510050633

Abstract

 Comparison of human and mouse genomic sequence at the border of the major histocompatibility complex (MHC) class II and class III regions revealed a locus encoding six exons with homology to the butyrophilin gene family and the location of a previously decribed gene, testis-specific basic protein (TSBP). We named the new locus BTL-II, for butyrophilin-like MHC class II associated. The six discernable exons of the BTL-II locus encode a small hydrophobic amino acid sequence (which may be a signal peptide), two immunoglobulin domains, a small 7-amino acid, heptad repeat-like exon, and a further two immunoglobulin domains. In mouse, an additional butyrophilin-like gene (NG10) is situated adjacent to BTL-II. Expression studies of the BTL-II locus in mouse showed that it is expressed in a range of gut tissues. We demonstrate that like many other genes from the MHC, BTL-II is polymorphic in a selection of diverse HLA haplotypes. In the light of the newly discovered locus, we revisit and discuss the possible origin of the butyrophilin gene family

Key words ButyrophilinImmunoglobulin superfamilyPolymorphismMHCTestis-specific basic protein
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© Springer-Verlag Berlin Heidelberg 2000