Immunogenetics

, Volume 47, Issue 4, pp 305–309

Structure of the human CD94 C-type lectin gene

Authors

  • Antonio Rodríguez
    • Hospital de la Princesa, Universidad Autónoma de Madrid, Servicio de Inmunología, Diego de León, 62, E-28006 Madrid, Spain
  • Marta Carretero
    • Hospital de la Princesa, Universidad Autónoma de Madrid, Servicio de Inmunología, Diego de León, 62, E-28006 Madrid, Spain
  • Jens Glienke
    • Max-Planck-Institut für Molekulare Genetik, Berlin (Dahlem), Germany
  • Teresa Bellón
    • Hospital de la Princesa, Universidad Autónoma de Madrid, Servicio de Inmunología, Diego de León, 62, E-28006 Madrid, Spain
  • A. Ramírez
    • Hospital de la Princesa, Universidad Autónoma de Madrid, Servicio de Inmunología, Diego de León, 62, E-28006 Madrid, Spain
  • Hans Lehrach
    • Max-Planck-Institut für Molekulare Genetik, Berlin (Dahlem), Germany
  • Fiona Francis
    • Max-Planck-Institut für Molekulare Genetik, Berlin (Dahlem), Germany
  • M. López-Botet
    • Hospital de la Princesa, Universidad Autónoma de Madrid, Servicio de Inmunología, Diego de León, 62, E-28006 Madrid, Spain
ORIGINAL PAPER

DOI: 10.1007/s002510050362

Cite this article as:
Rodríguez, A., Carretero, M., Glienke, J. et al. Immunogenetics (1998) 47: 305. doi:10.1007/s002510050362
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Abstract

 The genomic structure of the human CD94 gene was obtained by analyzing genomic clones obtained from two different libraries. The CD94 gene contains six exons separated by five introns. The carbohydrate-recognition domain (CRD) is encoded by three exons, and the conservation of intron positions within the CRD indicated that CD94 is closely related to group V of C-type lectins. Primer extension and S1 nuclease protection assays showed that initiation of transcription in the CD94 gene is heterogeneous, but restricted to a 60 base pair region around the major initiation site enclosed within a putative initiator element (TTA+1TTCA). The study of the promoter region of CD94 may help to understand the selective expression of this C-type lectin glycoprotein on NK cells and subsets of cytotoxic T cells.

Key words CD94GeneNK cellC-type lectinChromosome 12
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© Springer-Verlag Berlin Heidelberg 1998