Immunogenetics

, Volume 46, Issue 4, pp 307–311

The human natural killer gene complex is located on chromosome 12p12-p13

Authors

  • Mónica Renedo
    • Unidad de Biología Molecular, Hospital de la Princesa, Universidad Autónoma de Madrid, c/Diego de León 62, Madrid 28006, Spain
  • Ignacio Arce
    • Unidad de Biología Molecular, Hospital de la Princesa, Universidad Autónoma de Madrid, c/Diego de León 62, Madrid 28006, Spain
  • Antonio Rodríguez
    • Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain
  • Marta Carretero
    • Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain
  • Lewis L. Lanier
    • Department of Human Immunology, DNAX Research Institute of Molecular and Cell Biology, Palo Alto, CA 94304, USA
  • Miguel López-Botet
    • Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain
  • E. Fernández-Ruiz
    • Unidad de Biología Molecular, Hospital de la Princesa, Universidad Autónoma de Madrid, c/Diego de León 62, Madrid 28006, Spain
ORIGINAL PAPER

DOI: 10.1007/s002510050276

Cite this article as:
Renedo, M., Arce, I., Rodríguez, A. et al. Immunogenetics (1997) 46: 307. doi:10.1007/s002510050276

Abstract

 Natural killer (NK) cells preferentially express several type II glycoproteins of the calcium-dependent lectin superfamily. The genes coding for these molecules are clustered on the distal mouse chromosome 6 and on the rat chromosome 4 in a region designated the NK gene complex. To date, no definite evidence of the presence of a NK gene complex has been found in humans. Here we report the assignment by fluorescence in situ hybridization of the CD94 gene to human chromosome 12p12-p13, in the same region where the CD69 and NKG2A genes had been previously mapped. In addition, using a yeast artificial chromosome contig spanning this region we determined that the human CD94, NKG2A, NKG2C, NKG2E, and NKR-P1A (NKR) genes map to the short arm of chromosome 12. The distal to proximal position of these loci are: NKR- CD69 - CD94/NKG2A/NKG2C/NKG2E. These data demonstrate the existence of a human NK gene complex located within a 5.6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997