ORIGINAL PAPER

Immunogenetics

, Volume 51, Issue 2, pp 108-116

First online:

Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes

  • A. SatoAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , F. FigueroaAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , B. W. MurrayAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , E. Málaga-TrilloAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , Z. Zaleska-RutczynskaAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , H. SültmannAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , S. ToyosawaAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437
  • , C. WedekindAffiliated withAbteilung Verhaltensökologie, Zoologisches Institut, Universität Bern, Switzerland
  • , N. SteckAffiliated withAbteilung Verhaltensökologie, Zoologisches Institut, Universität Bern, Switzerland
    • , J. KleinAffiliated withMax-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437

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Abstract

 In tetrapods, the functional (classical) class I and class II B loci of the major histocompatibility complex (Mhc) are tightly linked in a single chromosomal region. In an earlier study, we demonstrated that in the zebrafish, Danio rerio, order Cypriniformes, the two classes are present on different chromosomes. Here, we show that the situation is similar in the stickleback, Gasterosteus aculeatus, order Gasterosteiformes, the common guppy, Poecilia reticulata, order Cyprinodontiformes, and the cichlid fish Oreochromis niloticus, order Perciformes. These data, together with unpublished results from other laboratories suggest that in all Euteleostei, the classical class I and class II B loci are in separate linkage groups, and that in at least some of these taxa, the class II loci are in two different groups. Since Euteleostei are at least as numerous as tetrapods, in approximately one-half of jawed vertebrates, the class I and class II regions are not linked.

Key words Gasterosteus aculeatus Poecilia reticulata Oreochromis niloticus Gene families Mhc organization