Immunogenetics

, Volume 65, Issue 1, pp 17–24

Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice

Authors

  • Tamio Ohno
    • Division of Experimental AnimalsNagoya University Graduate School of Medicine
  • Masakazu Okamoto
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
  • Toru Hara
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
  • Naozumi Hashimoto
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
  • Kazuyoshi Imaizumi
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
  • Miyoko Matsushima
    • Department of Pathophysiological Laboratory SciencesNagoya University Graduate School of Medicine
  • Masahiko Nishimura
    • Division of Experimental AnimalsNagoya University Graduate School of Medicine
  • Kaoru Shimokata
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
  • Yoshinori Hasegawa
    • Department of Respiratory MedicineNagoya University Graduate School of Medicine
    • Department of Pathophysiological Laboratory SciencesNagoya University Graduate School of Medicine
Original Paper

DOI: 10.1007/s00251-012-0656-7

Cite this article as:
Ohno, T., Okamoto, M., Hara, T. et al. Immunogenetics (2013) 65: 17. doi:10.1007/s00251-012-0656-7

Abstract

Asthma is regarded as a multifactorial inflammatory disorder arising as a result of inappropriate immune responses in genetically susceptible individuals to common environmental antigens. However, the precise molecular basis is unknown. To identify genes for susceptibility to three asthma-related traits, airway hyperresponsiveness (AHR), eosinophil infiltration, and allergen-specific serum IgE levels, we conducted a genetic analysis using SMXA recombinant inbred (RI) strains of mice. Quantitative trait locus analysis detected a significant locus for AHR on chromosome 17. For eosinophil infiltration, significant loci were detected on chromosomes 9 and 16. Although we could not detect any significant loci for allergen-specific serum IgE, analysis of consomic strains showed that chromosomes 17 and 19 carried genes that affected this trait. We detected genetic susceptibility loci that separately regulated the three asthma-related phenotypes. Our results suggested that different genetic mechanisms regulate these asthma-related phenotypes. Genetic analyses using murine RI and consomic strains enhance understanding of the molecular mechanisms of asthma in human.

Keywords

Airway hyperresponsivenessAsthmaEosinophilIgEMouseQTL analysis

Copyright information

© Springer-Verlag Berlin Heidelberg 2012