Immunogenetics

, Volume 62, Issue 9, pp 569–584

Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species

Authors

    • Institut für Immungenetik, Charité-Universitätsmedizin BerlinFreie Universität Berlin
    • Leibniz Institute for Zoo and Wildlife Research (IZW), Evolutionary Genetics
    • Institut für Immungenetik, Charité-Universitätsmedizin Berlin, Campus Benjamin FranklinFreie Universität Berlin
  • Thomas Kellermann
    • Institut für Immungenetik, Charité-Universitätsmedizin BerlinFreie Universität Berlin
  • Barbara Uchanska-Ziegler
    • Institut für Immungenetik, Charité-Universitätsmedizin BerlinFreie Universität Berlin
    • Institut für Immungenetik, Charité-Universitätsmedizin BerlinFreie Universität Berlin
    • Institut für Immungenetik, Charité-Universitätsmedizin Berlin, Campus Benjamin FranklinFreie Universität Berlin
Review

DOI: 10.1007/s00251-010-0468-6

Cite this article as:
Santos, P.S.C., Kellermann, T., Uchanska-Ziegler, B. et al. Immunogenetics (2010) 62: 569. doi:10.1007/s00251-010-0468-6

Abstract

The recent sequencing and assembly of the genomes of different organisms have shown that almost all vertebrates studied in detail so far have one or more clusters of genes encoding odorant receptors (OR) in close physical linkage to the major histocompatibility complex (MHC). It has been postulated that MHC-linked OR genes could be involved in MHC-influenced mate choice, comprising both pre- as well as post-copulatory mechanisms. We have therefore carried out a systematic comparison of protein sequences of these receptors from the genomes of man, chimpanzee, gorilla, orangutan, rhesus macaque, mouse, rat, dog, cat, cow, pig, horse, elephant, opossum, frog and zebra fish (amounting to a total of 559 protein sequences) in order to identify OR families exhibiting evolutionarily conserved MHC linkage. In addition, we compared the genomic structure of this region within these 16 species, accounting for presence or absence of OR gene families, gene order, transcriptional orientation and linkage to the MHC or framework genes. The results are presented in the form of gene maps and phylogenetic analyses that reveal largely concordant repertoires of gene families, at least among tetrapods, although each of the eight taxa studied (primates, rodents, ungulates, carnivores, proboscids, marsupials, amphibians and teleosts) exhibits a typical architecture of MHC (or MHC framework loci)-linked OR genes. Furthermore, the comparison of the genomic organization of this region has implications for phylogenetic relationships between closely related taxa, especially in disputed cases such as the evolutionary history of even- and odd-toed ungulates and carnivores. Finally, the largely conserved linkage between distinct OR genes and the MHC supports the concept that particular alleles within a given haplotype function in a concerted fashion during self-/non-self-discrimination processes in reproduction.

Keywords

MHCOdorant receptorGABAB receptorLinkage disequilibriumEvolution of mammals

Copyright information

© Springer-Verlag 2010