Immunogenetics

, Volume 61, Issue 9, pp 649–655

FcεRIα gene –18483A>C polymorphism affects transcriptional activity through YY1 binding

  • Daniel P. Potaczek
  • Keiko Maeda
  • Qing-Hui Wang
  • Nobuhiro Nakano
  • Shunsuke Kanada
  • Ewa Stepien
  • Agnieszka Branicka
  • Tatsuo Fukai
  • Mutsuko Hara
  • Tomoko Tokura
  • Hideoki Ogawa
  • Anetta Undas
  • Ko Okumura
  • Chiharu Nishiyama
Brief Communication

DOI: 10.1007/s00251-009-0391-x

Cite this article as:
Potaczek, D.P., Maeda, K., Wang, Q. et al. Immunogenetics (2009) 61: 649. doi:10.1007/s00251-009-0391-x

Abstract

Three frequent genetic polymorphisms in the human high-affinity IgE receptor α-subunit (FcεRIα) were shown to be associated with allergic disorders and/or total serum IgE levels in allergic patients. Two of these were previously demonstrated to affect FcεRIα expression while the third –18483A>C (rs2494262) has not yet been subjected to functional studies. We hypothesized that the –18483A>C variant affects transcriptional activity of the FcεRIα distal promoter in monocytes in which FcεRIα transcription is driven through that regulatory region. Indeed, we confirmed preferential binding of the YY1 transcription factor to the –18483C allele, resulting in lower transcriptional activity when compared with the –18483A allele.

Keywords

FcεRIαMonocytesPolymorphismYY1FCER1A

Supplementary material

251_2009_391_MOESM1_ESM.doc (79 kb)
(DOC 80 kb)

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Daniel P. Potaczek
    • 1
  • Keiko Maeda
    • 1
  • Qing-Hui Wang
    • 1
    • 2
  • Nobuhiro Nakano
    • 1
  • Shunsuke Kanada
    • 1
    • 3
  • Ewa Stepien
    • 4
  • Agnieszka Branicka
    • 4
  • Tatsuo Fukai
    • 1
    • 5
  • Mutsuko Hara
    • 1
  • Tomoko Tokura
    • 1
  • Hideoki Ogawa
    • 1
  • Anetta Undas
    • 6
  • Ko Okumura
    • 1
    • 3
  • Chiharu Nishiyama
    • 1
  1. 1.Atopy (Allergy) Research CenterJuntendo University School of MedicineTokyoJapan
  2. 2.Department of Immunology, College of Basic Medical SciencesChina Medical UniversityShenyangChina
  3. 3.Department of ImmunologyJuntendo University School of MedicineTokyoJapan
  4. 4.John Paul II HospitalKrakowPoland
  5. 5.Department of DermatologyJuntendo University School of MedicineTokyoJapan
  6. 6.Institute of CardiologyJagiellonian University School of MedicineKrakowPoland