Immunogenetics

, Volume 58, Issue 1, pp 31–40

Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

Authors

  • Patoula G. Panagos
    • Department of BiologyUniversity of South Florida
  • Kimberly P. Dobrinski
    • Department of BiologyUniversity of South Florida
  • Xianghong Chen
    • Immunology ProgramH. Lee Moffitt Cancer and Research Institute
  • Amanda W. Grant
    • Department of Molecular Biomedical Sciences, College of Veterinary MedicineNorth Carolina State University
  • David Traver
    • Division of Biological Sciences, Section of Cell and Developmental BiologyUniversity of California
  • Julie Y. Djeu
    • Immunology ProgramH. Lee Moffitt Cancer and Research Institute
  • Sheng Wei
    • Immunology ProgramH. Lee Moffitt Cancer and Research Institute
    • Department of Molecular Biomedical Sciences, College of Veterinary MedicineNorth Carolina State University
Original Paper

DOI: 10.1007/s00251-005-0064-3

Cite this article as:
Panagos, P.G., Dobrinski, K.P., Chen, X. et al. Immunogenetics (2006) 58: 31. doi:10.1007/s00251-005-0064-3

Abstract

The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.

Keywords

C-type lectinITIMNatural killer cellsSignaling motifs

Copyright information

© Springer-Verlag 2006