Immunogenetics

, Volume 58, Issue 1, pp 31–40

Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

  • Patoula G. Panagos
  • Kimberly P. Dobrinski
  • Xianghong Chen
  • Amanda W. Grant
  • David Traver
  • Julie Y. Djeu
  • Sheng Wei
  • Jeffrey A. Yoder
Original Paper

DOI: 10.1007/s00251-005-0064-3

Cite this article as:
Panagos, P.G., Dobrinski, K.P., Chen, X. et al. Immunogenetics (2006) 58: 31. doi:10.1007/s00251-005-0064-3

Abstract

The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.

Keywords

C-type lectinITIMNatural killer cellsSignaling motifs

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Patoula G. Panagos
    • 1
  • Kimberly P. Dobrinski
    • 1
  • Xianghong Chen
    • 2
  • Amanda W. Grant
    • 3
  • David Traver
    • 4
  • Julie Y. Djeu
    • 2
  • Sheng Wei
    • 2
  • Jeffrey A. Yoder
    • 3
  1. 1.Department of BiologyUniversity of South FloridaTampaUSA
  2. 2.Immunology ProgramH. Lee Moffitt Cancer and Research InstituteTampaUSA
  3. 3.Department of Molecular Biomedical Sciences, College of Veterinary MedicineNorth Carolina State UniversityRaleighUSA
  4. 4.Division of Biological Sciences, Section of Cell and Developmental BiologyUniversity of CaliforniaLa JollaUSA
  5. 5.College of MedicineUniversity of South FloridaTampaUSA